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Van Der Voort Lucht en Milieu Amste
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Van Der Voort Lucht en Milieu Amste
Catalog Number:
(102513-060)
Supplier:
Adipogen
Description:
Human perforin (cytolysin) is believed to be one of the major effector molecules used by cytotoxic T cells and NK cells to mediate targeted cell lysis. Perforin expression is constitutive on NK cells, but increases in resting CD8+ cytotoxic cells upon activation.
Supplier:
Adipogen
Description:
Used in the preparation of electrolyte suitable for lithium batteries showing very high conductivity. Used in the preparation of a chiral imidazolium salt via anion metathesis of the corresponding triflate.
Supplier:
Adipogen
Description:
Genotoxic mycotoxin. Antitumor compound. Potent iNOS (NOSII) inhibitor. Interferes with cellular respiratory processes.
Catalog Number:
(102988-432)
Supplier:
Adipogen
Description:
Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Asialo-ganglioside GM2 is a major neural ganglioside in Tay Sachs and Sandhoff diseases.
Supplier:
Adipogen
Description:
Building block for synthesis.
Supplier:
Adipogen
Description:
E7080 is an orally active inhibitor of multiple receptor tyrosine kinases including VEGF, FGF and SCF receptors. It is most potent against VEGFR2(KDR)/VEGFR3(Flt-4), with IC(50) values of 4nM and 5.2nM respectively.
Supplier:
Adipogen
Description:
A neonicotinoid insecticide. Compound can be used as analytical reference material.
Supplier:
Adipogen
Description:
Potent inhibitor of human 5-lipoxygenase (5-LO)
Supplier:
Adipogen
Description:
Bone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup of the TGF-beta superfamily. It plays a dominant role in embryonic dorsalventral patterning, organogenesis, limb bud formation and bone formation and regeneration. BMP-2 signals through heterodimeric complexes composed of a type I receptor (Activin RI, BMP-RIA or BMP-RIB) and a type II receptor (BMP-RII or Activin RIIB). BMP-2 induces chondrocyte proliferation, endochondral bone formation, longitudinal bone growth and bone and cartilage repair. It induces ectopic bone formation or calcification by promoting osteogenic and chondrogenic differentiation in mesenchymal cells, stem cells and vascular smooth muscle cells. It also promotes the maintenance and repair of colonic epithelium, suppresses neuronal dopamine synthesis and release, induces apoptosis in medulloblastoma cells and is required for cardiac contractility.
Supplier:
Adipogen
Description:
Choline fungicide that inhibits spore germination of fungal spores by preventing the formation of appressoria that are necessary for infection of host plants. Possible secondary mode of action is stimulating the expression of host defence genes. Controls powdery mildew on cereals and grapevines. Compound can be used as analytical reference material.
Supplier:
Adipogen
Description:
XL765 is active against class I PI3K (IC(50) = 39, 113, 9 and 43nM for p110alpha, beta, gamma and delta, respectively). XL765 also inhibits DNA-PK (IC(50) = 150nM) and mTOR (IC(50) = 157nM)
Catalog Number:
(102989-018)
Supplier:
Adipogen
Description:
Eremophilane sesquiterpenoid. Inhibitor of HIV-1 Tat transduction. Phytotoxin. Mycotoxin.
Catalog Number:
(102511-900)
Supplier:
Adipogen
Description:
Human CD4 is a cell surface glycoprotein of 55kDa expressed on most thymocytes, on about two thirds of peripheral T cells and on some monocyte macrophage lineage cells. CD4 interacts with MHC Class II molecules in an accessory role during foreign antigen recognition by T cells. The extracellular portion of CD4 is an array of four Ig-like domains. The N-terminal region of CD4 is a receptor for the HIV-1 viral protein gp120.
Supplier:
Adipogen
Description:
APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. MultimericAPRILâ„¢ is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the N-terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells.
Supplier:
Adipogen
Description:
Primarily used as a histological dye to detect indoles. Reagent for the determination of aromatic amines. It is used for the rapid identification of bacteria containing apotryptophanase and tryptophanase enzyme systems. It is also particularly useful for localization of proanthocyanidins compounds in plants, resulting in a blue staining. Has been developed for flavanoids in beer and is used in forensics.
Catalog Number:
(102514-282)
Supplier:
Adipogen
Description:
RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. RIG-I is a member of the DEAD-box RNA helicases and is activated by cytoplasmic dsRNA and 5'-ppp RNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-1 recruits the CARD adaptor inducing IFN-beta (Cardif) in a CARD-CARD-dependent manner resulting in NF-kappaB and IRF3 activation.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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