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Van Der Voort Lucht en Milieu Amste
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Van Der Voort Lucht en Milieu Amste
Catalog Number:
(102512-742)
Supplier:
Adipogen
Description:
Human CD270 (Herpes Virus Entry Mediator; TNFRSF14; ATAR; LIGHTR; TR2) is a 36kDa type I membrane protein that has been found on a broad range of lymphoid tissues. Its ligands include the TNF ligand family members LTalpha and LIGHT and the CD28/Ig superfamily member BTLA.
Supplier:
Adipogen
Description:
Cell permeable, irreversible calmodulin antagonist. Acts by covalently binding to a lysine-rich inhibitory site. Inhibits by blocking the activation of the Ca2+/calmodulin-dependent phosphodiesterase. Herbicidal mycotoxin. Phytotoxic, antifungal, antibacterial and nematocidal compound. Anticancer compound. Shown to induce paraptosis-like cell death. Shown to inhibit P-glycoprotein-mediated transport.
Supplier:
Adipogen
Description:
Fluorescent dye. Spectral data: Extinction 504nm/Emmission 529nm, in 0.1 M Tris pH 8.0. Used for the determination of carbohydrates by fluorescence densitometry after TLC, in the determination of H2O2 by chemiluminescence, and as a fluorescent additive used in indirect fluorimetric detection in OTC-HPLC. Used as a component/substrate of the 2′,7′-dichlorofluorescein diacetate (DCFH-DA) assay to quantitate reactive oxygen species (ROS).
Supplier:
Adipogen
Description:
AV-412 is a potent dual inhibitor of EGFR and ErbB2 tyrosine kinases, including the mutant EGFR(L858R,T790M), which is clinically resistant to the EGFR-specific kinase inhibitors erlotinib and gefitinib. In enzyme assays assay the compound inhibited the EGFR variants and ErbB2 in the nanomolar range with over 100-fold selectivity compared with other kinases, apart from ABL and FLT1, which were both moderately sensitive to the compound. In cells, AV-412 inhibited autophosphorylation of EGFR and ErbB2 with IC(50) of 43 and 282 nM, respectively. It also inhibited epidermal growth factor (EGF)-dependent cell proliferation with an IC(50) of 100nM. Moreover, AV-412 abrogated EGFR signaling in the gefitinib-resistant H1975 cell line, which harbors a double mutation of L858R and T790M in EGFR. In animal studies using cancer xenograft models, AV-412 (30mg/kg) demonstrated complete inhibition of tumor growth of the A431 and BT-474 cell lines, which overexpress EGFR and ErbB2, respectively.
Catalog Number:
(102512-994)
Supplier:
Adipogen
Description:
Human CD117 (c-kit) is a transmembrane protein with receptor tyrosine kinase capacity and serves as the receptor for steel factor (SLF). CD117 is expressed on almost all hematopoietic progenitor cells and receptor/ligand interaction is crucial for development of hematopoietic stem cells.
Catalog Number:
(102511-754)
Supplier:
Adipogen
Description:
Human CD80 (B7-1) is a costimulatory ligand for CD28 and CD152 (CTLA-4). CD80 is expressed on activated B cells.
Supplier:
Adipogen
Description:
Vandetanib is a tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (VEGFR, IC(50) of 40nM) and the epidermal growth factor receptor (EGFR).
Supplier:
Adipogen
Description:
Plasminogen activator inhibitor (PAI-1). Glucose uptake stimulator.
Supplier:
Adipogen
Description:
Potent, cell permeable, highly specific, reversible PI(3)K (phosphoinositide 3-kinase) inhibitor. pan-class I / II / III PI3K inhibitor. Acts on the ATP-binding site of the enzyme. In solution more stable than wortmannin. Antagonizes P-glycoprotein-mediated multidrug resistance. Blocks Akt phosphorylation. Pim-1 kinase inhibitor. Autophagy inhibitor (autophagosome formation). Inhibitor of BET bromodomain proteins BRD2, BRD3 and BRD4.
Supplier:
Adipogen
Description:
Inhibitor of human leukocyte elastase (IC50 = 1.3 µg/ml), different other elastases and chymotrypsin (IC50 = 82 µg/ml).
Supplier:
Adipogen
Description:
Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Removing the sialic acid from monosialoganglioside GM1 inhibits its ability to bind cholera toxin. Asialo-ganglioside GM1 does not block the binding of cholera toxin to cellular GM1.
Supplier:
Adipogen
Description:
Chaetoglobosin A is a cytochalasan analog with anti-fungal activity.
Supplier:
Adipogen
Description:
Heterocyclic building block.
Supplier:
Adipogen
Description:
GDC-0941 is a potent class I PI3 kinase (PI3K) inhibitor. It selectively binds to PI3K isoforms in an ATP-competitive manner. It has an IC(50) of 3nM, and shows slight selectivity toward p110beta (11-fold) and p110gamma (25-fold).
Supplier:
Adipogen
Description:
alpha1-Adrenergic receptor (alpha-AR) antagonist. Prototypical calcium channel protein inhibitor that blocks the L-type Ca2+ channels in smooth and cardiac muscle cells. Vasodilator known to reduce the renal clearance of digoxin and used to control hypertension, angina, cardiac arrhythmia and vascular headaches. Apoptosis inducer in primary and metastatic colon adenocarcinoma human cell lines in vitro. Inhibitor of drug efflux pump proteins such as Mdr (P-glycoprotein) which are often over-expressed in certain tumor cell lines. Substrate of CYP3A4 and CYP2C6. Used in fluorescent cell sorting for DNA content, as it blocks efflux of a variety of DNA-binding fluorophores such as Hoechst 33342. Anti-diabetic in animal models by limiting TXNIP expression.
Catalog Number:
(102512-054)
Supplier:
Adipogen
Description:
Human CD15 is expressed by neutrophils, eosinophils and monocytes. Antibodies in this cluster recognize a common terminal pentasaccharide found on cell surface glycoproteins and glycolipids.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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