Print…
You Searched For:
2 results were found
(9H-Fluoren-9-yl)methyl (trans-4-aminocyclohexyl)carbamate hydrochloride
Catalog Number:
(103003-190)
Supplier:
Anaspec Inc
Description:
CREBtide is a synthetic substrate for PKA (Km = 3.9 µM). This peptide is based on the phosphorylation sequence in δ-CREB (cAMP response element binding protein).
Sequence:KRREILSRRPSYR MW:1717 Da % peak area by HPLC:95 Storage condition:-20° C
Catalog Number:
(103664-548)
Supplier:
Sino Biological
Description:
A DNA sequence encoding the extracellular domain (Ser 60-Asn 284) of mouse ASGPR1 (NP_033844.1) was expressed with a N-terminal polyhistidine tag.
Catalog Number:
(77437-472)
Supplier:
Bioss
Description:
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.
Catalog Number:
(103664-388)
Supplier:
Sino Biological
Description:
A DNA sequence encoding the mature form of mouse B7H4 (Q7TSP5) (phe 29-Ser 256) was fused with the Fc region of human IgG1 at the C-terminus.
Supplier:
Sino Biological
Description:
A DNA sequence encoding the mature form of mouse NGF (NP_001106168.1) (Ser 122-Gly 241) was expressed, with an initial Met at the C-terminus.
Supplier:
Sino Biological
Description:
A DNA sequence encoding the soluble form of mouse IL21 (Q9ES17) (Pro 25-Ser 146) was expressed, with an initial Met at the N-terminus.
Catalog Number:
(76653-458)
Supplier:
AMBEED, INC
Description:
(S)-Isopropyl 2-amino-3-hydroxypropanoate hydrochloride, Purity: 97%, CAS Number: 37592-53-3, Appearance: Solid, Storage: Inert atmosphere, Room Temperature, Size: 250MG
Catalog Number:
(76108-952)
Supplier:
Bioss
Description:
Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.
Catalog Number:
(103667-550)
Supplier:
Sino Biological
Description:
A DNA sequence encoding the pro form of mouse MMP8 (NP_032637.3) (Phe 21-Ser 465) was expressed and purified, with an initial Met at the N-terminus.
Catalog Number:
(10420-342)
Supplier:
Bioss
Description:
Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation.
Catalog Number:
(TCC1575-001G)
Supplier:
TCI America
Description:
CAS Number: 26054-60-4
MDL Number: MFCD01318309 Molecular Formula: C11H11NO4 Molecular Weight: 221.21 Purity/Analysis Method: >98.0% (HPLC) Form: Crystal Melting point (°C): 134 Specific rotation [a]20/D: -25.5 deg (C=1, CH3CN) Storage Temperature: 0-10°C
Catalog Number:
(103616-516)
Supplier:
Sino Biological
Description:
Produced in rabbits immunized with purified, recombinant Human HGF (rh HGF; Catalog#10463-H08H; NP_000592.3; Met 1-Ser 728). HGF specific IgG was purified by Human HGF affinity chromatography.
Supplier:
ACROBIOSYSTEMS INC MS
Description:
SARS-CoV-2 (COVID-19) NSP16&NSP10 Heterodimer Protein, His Tag&Twin Strep Tag, ACROBiosystems
Catalog Number:
(103668-346)
Supplier:
Sino Biological
Description:
A DNA sequence encoding the mouse IL12B (P43432) (Met 1-Ser 335) was fused with the Fc region of human IgG1 at the C-terminus.
Catalog Number:
(103669-244)
Supplier:
Sino Biological
Description:
A DNA sequence encoding the pro form of rat IL1B (Q63264-1) (Met 1-Ser 268) was fused with a polyhistidine tag at the N-terminus.
Catalog Number:
(103632-558)
Supplier:
Sino Biological
Description:
The 77 amino acid endothelial-cell derived form (Ala 23-Ser 99) of the mature human IL8 (NP_000575.1) was expressed and purified.
Inquire for Price
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
|
|||||||||
List View
