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EAGLE MHC
Catalog Number:
(100243-522)
Supplier:
Southern Biotechnology
Description:
CD45R, also known as B220, a member of the protein tyrosine phosphate family and a major cell surface glycoprotein, represents a restricted form of the CD45 family which primarily recognizes only cells of B-lineage from pro-B cell through mature B lymphocytes and prior to the availability of anti-CD19 monoclonal antibodies was commonly used as a pan B-cell marker. It also reacts with certain activated T cells as well as non-MHC-restricted lytically active lymphokine-activated killer (LAK) cells. In vivo administration of RA3-6B2 has been shown to affect differentiation of both T and B cells in normal mice and reduce the level of anti-DNA antibodies and lymphadenopathies in MRL/lpr mice.
Catalog Number:
(76235-586)
Supplier:
Rockland Immunochemical
Description:
Human CXCL7 AccuSignal ELISA Kit
Catalog Number:
(200063-318)
Supplier:
Enzo Life Sciences
Description:
Synapsin I, II and III belong to a family of neuron-specific phosphoproteins which maintain a reserve pool of vesicles in the vicinity of the active zone by tethering synaptic vesicles to each other and to an Actin-based cytoskeleton meshwork. They have been shown to regulate neurotransmitter release in mature synapses and to accelerate development of the nervous system.
Catalog Number:
(77437-836)
Supplier:
Bioss
Description:
Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. Isoform TrkA-III is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed.
Supplier:
BeanTown Chemical
Description:
CAS: 141-43-5; EC No: 205-483-3; MDL No: MFCD00008183; RTECS: KJ5775000
UN No: UN2491; Haz Class: 8; Packing Group: III
Liquid; Linear Formula: HOCH2CH2NH2; Molecular Formula: C2H7NO; MW: 61.08
Melting Point: 10-11°; Boiling Point: 170°; Flash point: 86°C (187°F)
Density (g/mL): 1.012; Refractive Index: 1.454
Air Sensitive , Hygroscopic
Catalog Number:
(76481-844)
Supplier:
AAT BIOQUEST INC
Description:
Stains-all is suitable for differential staining of nucleic acids and proteins.
Catalog Number:
(10452-250)
Supplier:
Bioss
Description:
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.
Supplier:
Bachem Americas
Description:
The sequences given for angiotensin I (H-1680) and II (H-1705) correspond to the sequences of human, horse, sheep, pig, mouse, and rat angiotensins I and II.
Catalog Number:
(10077-872)
Supplier:
Prosci
Description:
Sphingosine kinase (SPHK) phosphorylates sphingosine to form a bioactive lipid mediate, sphingosine 1-phosphate (S1P or SPP). S1P is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival while extracellularly it is a ligand for EDG 1. Expression of SPHK1 and subsequent production of S1P promotes the G1-S transition, protects cells from apoptosis, stimulates migration and angiogenesis, and induces tumor formation in mice.
Supplier:
BeanTown Chemical
Description:
CAS: 3236-82-6; EC No: 221-795-2; MDL No: MFCD00015122
UN No: UN2924; Haz Class: 3(8); Packing Group: III
Liquid; Linear Formula: Nb(OCH2CH3)5; MW: 318.21
Melting Point: 6°; Boiling Point: 142°/0.1 mmHg; Flash point: 36°C (97°F)
Density (g/mL): 1.268; Refractive Index: 1.516
Air Sensitive, Moisture Sensitive
Supplier:
BeanTown Chemical
Description:
CAS: 79-01-6; EC No: 201-167-4; MDL No: MFCD00000838; RTECS: KX4550000
UN No: UN1710; Haz Class: 6.1; Packing Group: III
Liquid; Linear Formula: ClCH=CCl2 ; Molecular Formula: C2HCl3; MW: 131.39
Melting Point: -85°; Boiling Point: 87°
Density (g/mL): 1.463; Refractive Index: 1.476
Light Sensitive
Supplier:
BeanTown Chemical
Description:
CAS: 821-41-0; EC No: 212-477-4; MDL No: MFCD00002981
UN No: UN2924; Haz Class: 3(8); Packing Group: III
Liquid; Linear Formula: HOCH2(CH2)3CH=CH2; Molecular Formula: C6H12O; MW: 100.16
Boiling Point: 78-80°/25 mmHg; Flash point: 47°C (117°F)
Density (g/mL): 0.834; Refractive Index: 1.435
Catalog Number:
(10346-266)
Supplier:
Bioss
Description:
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection.
Supplier:
BeanTown Chemical
Description:
CAS: 60-12-8; EC No: 200-456-2; MDL No: MFCD00002886; RTECS: SG7175000
UN No: UN2810; Haz Class: 6.1; Packing Group: III
Liquid; Linear Formula: C6H5CH2CH2OH; Molecular Formula: C8H10O; MW: 122.16
Melting Point: -27°; Boiling Point: 219-221°; Flash point: 102°C (215°F)
Density (g/mL): 1.02; Refractive Index: 1.532
Supplier:
BeanTown Chemical
Description:
CAS: 5329-14-6; EC No: 226-218-8; MDL No: MFCD00011603; RTECS: W05950000
UN No: UN2967; Haz Class: 8; Packing Group: III
Crystalline; Linear Formula: NH2SO3H; MW: 97.09
Melting Point: 215-225° (decomposes)
Supplier:
BeanTown Chemical
Description:
CAS: 58-08-2; EC No: 200-362-1; MDL No: MFCD00005758; RTECS: EV6475000
UN No: UN1544; Haz Class: 6.1; Packing Group: III
Powder; Molecular Formula: C8H10N4O2; MW: 194.19
Melting Point: 234-236°
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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