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Storage Cabinets
Catalog Number:
(89162-330)
Supplier:
Enzo Life Sciences
Description:
Studies have demonstrated that PR39, a proline/arginine rich 39 amino acid antibacterial peptide originally derived from porcine bone marrow, exhibits a broad spectrum of biological activities, including the ability to induce angiogenesis and to limit inflammatory damage in a variety of animal models. The angiogenic effect is in part explained by the ability of PR39 to inhibit proteasome-dependent degradation of the transcription factor HIF-1a, while anti-inflammatory activity is associated with inhibition of IκBα degradation that in turn prevents activation of NFκB-dependent gene expression. The activities of PR39 reside in the N-terminal portion of the molecule encompassed by PR11. The most recent findings have demonstrated that PR39 is a non-competitive and reversible inhibitor of the proteasome function, which is achieved by a unique allosteric mechanism allowing for specific inhibition of degradation of selected proteins without affecting total proteasome-dependent proteolysis. A proline-arginine-rich 11 amino acid peptide derived from the naturally occurring peptide antibiotic PR39. PR39 has been shown to act as an inhibitor of both 20S and 26S proteasomes with proposed selectivity for the inhibition of the degradation of IκBα, HIF-1a and certain other proteins. PR39 has been reported to inhibit the proteasomal degradation of IκBα without effecting overall proteasome activity, or degradation of p21Cip1/Waf1 and c-fos, cell-cycle genes regulated by proteasome-dependent degradation. In vitro studies have demonstrated PR39 to be an efficient inhibitor of all three activities of the 20S proteasome. Unlike MG132 and lactacystin, long-term exposure to PR39 shows little toxicity or induction of HSP-70. In mouse models of myocardial infarction it has been shown that infusion with PR11 results in a significant reduction of myocardial infarct size. PR39, PR11 and related peptides may therefore provide novel means to regulate cellular function and the control of NF-κB-dependent gene expression for therapeutic purposes.
Catalog Number:
(75928-512)
Supplier:
Rockland Immunochemical
Description:
Horse Albumin
Catalog Number:
(89156-654)
Supplier:
Enzo Life Sciences
Description:
Highly specific substrate for the caspase-like peptidic activity of the 20S proteasome.
Supplier:
Enzo Life Sciences
Description:
Produced in HEK 293 cells. The extracellular domain of human CD134L (OX40L) (aa 52-183) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG®-tag.
Catalog Number:
(89164-450)
Supplier:
Enzo Life Sciences
Description:
Produced in E. coli. Active catalytic domain of phosphodiesterase 4B2.
Catalog Number:
(89151-948)
Supplier:
Enzo Life Sciences
Description:
Produced in HEK 293 cells. The extracellular domain of mouse TWEAK (aa 94-249) is fused at the N-terminus to tenascin-C (TNC) (chicken) (aa 110-139) and a FLAG®-tag.
Catalog Number:
(89146-914)
Supplier:
Enzo Life Sciences
Description:
Cathepsin substrate
Catalog Number:
(89165-164)
Supplier:
Enzo Life Sciences
Description:
SUMO1-AMCA is a synthetic AMCA-peptide substrate based on the C-terminal residues of SUMO1 and is a useful fluorogenic substrate for deSUMOylating enzymes, including SENP1 (BML-UW9760). It has particular utility for the study of deSUMOylating activity where continuous monitoring of activity is essential. It provides an alternative substrate to SUMO1-AMC.
Catalog Number:
(89164-350)
Supplier:
Enzo Life Sciences
Description:
Produced in insect cells. Full length active enzyme.
Catalog Number:
(89161-624)
Supplier:
Enzo Life Sciences
Description:
Negative control for AAF-CMK
Supplier:
Rockland Immunochemical
Description:
Recombinant Human PDGF-BB control protein
Supplier:
Rockland Immunochemical
Description:
Recombinant Rat CCL2 control protein
Supplier:
Rockland Immunochemical
Description:
Recombinant Human IL-4 control protein
Catalog Number:
(89165-288)
Supplier:
Enzo Life Sciences
Catalog Number:
(89161-046)
Supplier:
Enzo Life Sciences
Description:
DPP substrate
Supplier:
Rockland Immunochemical
Description:
Recombinant Mouse INF gamma control protein
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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