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Proteins and Peptides
Supplier:
Rockland Immunochemical
Description:
Recombinant Human IGF-I control protein
Supplier:
Rockland Immunochemical
Description:
Recombinant Human NGF beta control protein
Catalog Number:
(89160-282)
Supplier:
Enzo Life Sciences
Description:
Fluor de Lys® Substrate is a highly sensitive and convenient alternative to radiolabeled, acetylated histones or peptide/HPLC methods for the assay of histone deacetylases. The Fluor de Lys® Substrate, which comprises an acetylated lysine side chain, is incubated with a sample containing HDAC activity (nuclear or cellular extract, purified enzyme, bead-bound immunocomplex, etc.). Deacetylation of the substrate sensitizes the substrate so that, in a second step, treatment with the Fluor de Lys® Developer produces a fluorophore. Histone deacetylases from all known classes have been successfully assayed with the Fluor de Lys® Substrate. These include human HDACs 1, 2, 3 and 8 (class I), human HDACs 4 and 9 (class II) and the sirtuins yeast Sir2, human SIRT1 and human SIRT2 (class III; reaction must include the sirtuin substrate NAD+). The substrate is cell-permeable and serves as the basis for the HDAC Cellular Activity Assay Kit (Prod. No. BML-AK503). NOTE: Must be used in conjunction with Fluor de Lys® Developer (Prod. No. BML-KI105). Sufficient for 100-1000 assays of HDACs or sirtuins (50 µl reaction volume, 50-500 µM (substrate).
Catalog Number:
(89161-104)
Supplier:
Enzo Life Sciences
Description:
14-3-3 inhibitor
Catalog Number:
(76222-532)
Supplier:
Rockland Immunochemical
Description:
ERK2 Internal Blocking Control Peptide
Catalog Number:
(RL009-001-C27)
Supplier:
Rockland Immunochemical
Description:
BDNF is a member of the nerve growth factor family of trophic factors. In the brain BDNF has a trophic action on retinal, cholinergic, and dopaminergic neurons, and in the peripheral nervous system it acts on both motor and sensory neurons. Some protein domains of BDNF are identical with those of NGF and another neurotrophic factor, designated NT-3 (neurotrophin-3). It exists as monomers and homodimers, and binds to NTRK2/TRKB. Polyclonal antibodies raised against murine NGF have been shown to cross-react with both NT-3 and BDNF. The propeptide is N-glycosylated and glycosulfated. BDNF is converted into mature BDNF by plasmin (PLG). It is expressed in brain, and highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum; it is also expressed in heart, lung, skeletal muscle, testis, prostate and placenta. Recombinant Human Brain-Derived Neurotrophic Factor produced in E.coli is a homodimer, non-glycosylated, polypeptide chain containing 2 x 119 amino acids and having a total molecular mass of 26,984 Daltons.
Catalog Number:
(89148-688)
Supplier:
Enzo Life Sciences
Description:
Semisynthetic (from GM1).
Catalog Number:
(10801-850)
Supplier:
Rockland Immunochemical
Description:
AKT1 is a component of the PI-3 kinase pathway and is activated by phosphorylation at Ser 473 and Thr 308. AKT is a cytoplasmic protein also known as Protein Kinase B (PKB) and RAC (Related to A and C kinases). AKT is a key regulator of many signal transduction pathways, and it exhibits tight control over cell proliferation and cell viability. Overexpression or inappropriate activation of AKT is noted in many types of cancer. AKT mediates many of the downstream events of PI 3-kinase (a lipid kinase activated by growth factors, cytokines and insulin). PI 3-kinase recruits AKT to the membrane, where it is activated by PDK1 phosphorylation. Once phosphorylated, AKT dissociates from the membrane and phosphorylates targets in the cytoplasm and the cell nucleus. AKT has two main roles: (i) inhibition of apoptosis; (ii) promotion of proliferation. AKT1 mutant (T308 / S473A) recombinant protein is ideal for investigators involved in Cell Signaling, Neuroscience and Signal Transduction research.
Supplier:
Rockland Immunochemical
Description:
Recombinant Human PDGF-AA control protein
Catalog Number:
(75932-728)
Supplier:
Rockland Immunochemical
Description:
Tau-441 (S198E) control protein
Catalog Number:
(89156-656)
Supplier:
Enzo Life Sciences
Description:
This fluorogenic peptide is often the substrate of choice for assaying the trypsin-like activity of purified proteasomes. Benefits include a low Km, high specific activity, and the fact that the substrate is cleaved exclusively at the R-AMC bond.
Catalog Number:
(89146-760)
Supplier:
Enzo Life Sciences
Description:
Caspase-9 inhibitor
Catalog Number:
(89144-334)
Supplier:
Enzo Life Sciences
Description:
Produced in SF21 cells. Human PARP-1 (aa 656-1014) is fused to a His-tag.
Catalog Number:
(76222-522)
Supplier:
Rockland Immunochemical
Description:
MEK2 N-Term Blocking Control Peptide
Catalog Number:
(10033-560)
Supplier:
Enzo Life Sciences
Description:
Highly active
Catalog Number:
(76045-552)
Supplier:
Enzo Life Sciences
Description:
Isolated from rat tail tendons.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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