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Supplier:
Adipogen
Description:
LDK378 is potent inhibitor against ALK with IC(50) of 0.2nM, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively.
Supplier:
Adipogen
Description:
Canertinib is an orally bio-available EGFR inhibitor with potential anti-neoplastic and radio-sensitizing activities. It has IC(50) values of 1.5nM and 9.0nM against EGFR and ErbB2 respectively, with no activity against PDGFR, FGFR, InsR, PKC, or CDK1/2/4.
Supplier:
Adipogen
Description:
Regorafenib (BAY 73-4506, Fluoro-Sorafenib) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFR, Kit, RET and Raf-1 with IC(50) values of 13, 4.2, 46, 22, 7, 1.5 and 2.5nM, respectively.
Supplier:
Adipogen
Description:
Used to inhibit and study the mechanism of autophagy (lysosomal self-degradation) and apoptosis under various conditions. Inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K).
Supplier:
BeanTown Chemical
Description:
CAS: 32634-66-5; EC No: 251-131-7; MDL No: MFCD00064440
Powder; Molecular Formula: C20H18O8; MW: 386.35
Melting Point: 169-171°
Optical Rotation: [α]20/D -138°, c = 1 in ethanol
Supplier:
Spectrum Chemicals
Description:
Potassium Acetate, BiotechGrade is used in molecular biology to precipitate dodecyl sulfate (DS) and DS-bound proteins, allowing the removal of proteins from DNA. It is also used as a salt for the ethanol precipitation of DNA. Potassium acetate is also used in mixtures applied for tissue preservation, fixation, and mummification.
Supplier:
Adipogen
Description:
IPI-145 is a potent, oral inhibitor of Class I phosphoinositide-3-kinase (PI3K)-delta and PI3K-gamma (IC(50) of 243 pM and 50nM), and is clinically active in patients with advanced hematological malignancies.
Supplier:
Adipogen
Description:
Anticancer compound. Caspase-independent, non-apoptotic cell death inducer. ATP-competitive Flt3 inhibitor. Necrosis inducer. Aurora B and C kinase inhibitor. DYRK1A and DYRK 2 (Dual-specificity tyrosine phosphorylation-regulated kinase) inhibitor. Inflammasome activator.
Supplier:
Adipogen
Description:
PIK-90 is a potent PI3K inhibitor with IC(50) values of 11, 18, and 58nM for p110alpha, gamma and delta isoforms respectively. It has an IC(50) of 350nM for the p110beta isoform. It also has low mTOR activity.
Supplier:
Adipogen
Description:
Lapatinib is an ATP-competitive epidermal growth factor receptor (EGFR) and HER2/neu (ErbB-2) dual tyrosine kinase inhibitor, with IC(50) values of 10.8 and 9.2nM respectively. It is an orally active drug for treatment of breast cancer and other solid tumors.
Supplier:
Adipogen
Description:
GW441756 is an orally active, potent and highly selective TrkA tyrosine kinase inhibitor (IC(50) of 2nM). It specifically blocks TrkA-induced cell death in a dose-dependent manner.
Supplier:
Adipogen
Description:
SB-590885 is a novel, potent and selective small molecule inhibitor of B-Raf kinase, with a Ki of 0.16nM. It shows an 11-fold greater selectivity for B-Raf over c-Raf. It was used to address the dependence of MAPK signalling and tumor cell growth on B-Raf kinase activity.
Supplier:
AOB CHEM USA
Description:
4-Chloro-2,3-difluorobenzaldehyde ≥97%
Supplier:
Adipogen
Description:
XL765 is active against class I PI3K (IC(50) = 39, 113, 9 and 43nM for p110alpha, beta, gamma and delta, respectively). XL765 also inhibits DNA-PK (IC(50) = 150nM) and mTOR (IC(50) = 157nM)
Supplier:
AOB CHEM USA
Description:
5-Chloro-2,3-dimethoxybenzaldehyde ≥97%
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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