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2-(2-Methylphenyl)ethanol
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2-(2-Methylphenyl)ethanol
Supplier:
Adipogen
Description:
Afatinib is an irreversible kinase inhibitor and binds to the kinase domains of EGFR (ErbB1), HER2 (ErbB2), and HER4 (ErbB4) to inhibit tyrosine kinase autophosphorylation. This results in a downregulation of ErbB signaling and subsequent inhibition of proliferation of cell lines expressing wild-type EGFR, selected EGFR exon 19 deletion mutations, or exon 21 L858R mutations. It also inhibited in vitro proliferation of cell lines overexpressing HER2. Overall, tumor growth was inhibited by Afatinib very effectively with low nanomolar IC(50) values ranging from approximately 6nM to below 500nM.
Supplier:
Thermo Scientific Chemicals
Description:
Hydrosilation, isomerization, carbonylation, oxidation, and C-C bond formation
Supplier:
Adipogen
Description:
Precursor of cholesterol and vitamin D3. It is reduced to cholesterol by the enzyme 3beta-hydroxysterol-Delta7-reductase (DHCR7) in the last step of cholesterol biosynthesis. Mutations in the gene encoding DHCR7 lead to increased levels of 7-DHC and the neurodevelopmental syndrome Smith-Lemli-Opitz syndrome (SLOS). 7-DHC is used as a biomarker for SLOS screenings. Inhibits human fibroblast sphingomyelinase. Shown to have cytotoxic effects on melanoma cells. In skin, photolysis of 7-DHC by ultraviolet light produces vitamin D3. UV/Vis: lambdamax 271, 282, 293nm.
Catalog Number:
(95026-726)
Supplier:
GE Healthcare - Life Sciences
Description:
The illustraâ„¢ GFXâ„¢ 96 Purification Kit utilises glass fibre matrix technology in a 96-well format for highly efficient purification of PCR products. Fragments from PCR are captured by the matrix in the presence of a chaotropic salt, and contaminants are conveniently removed by washing the matrix with a buffered ethanol solution.
Supplier:
Adipogen
Description:
Chirality inducing agent. Useful tool as resolving agent to separate the isomers and purify racemic mixtures (e.g. DL-lysine) by fractionally crystallizing the product to obtain the pure isomer (e.g. D-lysine). Can also be used as building block.
Catalog Number:
(700003-464)
Supplier:
Spectrum Chemicals
Description:
2-Ethoxyethanol, Reagent is a clear and colorless liquid that is water miscible and also referred to as ethyl cellosolve, a widely used solvent. It is used to dissolve chemically diverse compounds such as oils, resins, waxes among others. Its reagent grade means this is the highest quality commercially available for this chemical and that the American Chemical Society has not officially set any specifications for this material.
Supplier:
Adipogen
Description:
Highly potent, selective and reversible cell permeable inhibitor of the proteasome. Inhibits the chymotrypsin-like and caspase-like peptidase activity of the proteasome. Calpain and cathepsin inhibitor. Autophagy activator. Anticancer compound. Inhibits proliferation and migration of several tumor cell lines with nanomolar potency. Apoptosis inducer.
Supplier:
Thermo Scientific Chemicals
Description:
For cleavage of disulfide bonds, as a polymerization crosslinking catalyst, as an organic intermediate, and in fuels
Supplier:
Adipogen
Description:
Potent cell permeable JAK3 inhibitor (IC50 = 1nM). Shows also JAK-1 inhibitory activity. Immunosuppressive and anti-inflammatory agent. Inhibits signaling through heterodimeric receptors associated with JAK3, JAK1, or both of them, with functional selectivity over JAK2-paired receptors. Blocks downstream STAT signaling, resulting in potent inhibition of several cytokines, including interleukins 2, 4, 7, 9, 15 and 21, which are integral to lymphocyte activation, function and proliferation. Investigated for several autoimmune disorders including, rheumatoid arthritis and psoriasis. Potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro.
Supplier:
Adipogen
Description:
Anti-hypercholestrolemic compound. Anti-inflammatory and immune-modulating effects. Anticancer compound. Chemopreventive. Cytostatic. Cell growth inhibitor. Antimutagenic. Potent in vitro antagonist of FXR (farnesoid X receptor). DNA polymerase beta inhibitor. Potent antioxidant, hypoglycemic and thyroid inhibiting agent. Anti-osteoarthritic. Decreases the expression of matrix metalloproteinases. Neuroprotective. Is used as a precursor for synthetic progesterone and vitamin D3 and is an intermediate in the biosynthesis of androgens, estrogens and corticoids.
Supplier:
Adipogen
Description:
Keto acid that is involved in the tyrosine catabolism pathway. It is a product of the enzyme (R)-4-hydroxyphenyllactate dehydrogenase and is formed during tyrosine metabolism. The conversion from tyrosine to 4-HPPA is catalyzed by tyrosine aminotransferase. 4-HPPA can be converted to homogentisic acid which is one of the precursors to ochronotic pigment. A deficiency in the catalytic activity of HPD is known to lead to tyrosinemia type III, an autosomal recessive disorder characterized by elevated levels of blood tyrosine and massive excretion of tyrosine derivatives into urine.
Supplier:
BeanTown Chemical
Description:
CAS: 60-12-8; EC No: 200-456-2; MDL No: MFCD00002886; RTECS: SG7175000
UN No: UN2810; Haz Class: 6.1; Packing Group: III
Liquid; Linear Formula: C6H5CH2CH2OH; Molecular Formula: C8H10O; MW: 122.16
Melting Point: -27°; Boiling Point: 219-221°; Flash point: 102°C (215°F)
Density (g/mL): 1.02; Refractive Index: 1.532
Catalog Number:
(80052-244)
Supplier:
MilliporeSigma
Description:
A synthetic amide of all-trans retinoic acid (RA) that displays reduced toxicity relative to RA while maintaining significant biological activity
Supplier:
MP Biomedicals
Description:
Acrylamide is a monomer used in a variety of synthetic processes to form polymers and copolymers. It polymerizes in the presence of free radicals in aqueous solutions. It is usually used to prepare polyacrylamide gels for electrophoresis separation of biomolecules.
Supplier:
Honeywell Research Chemicals
Description:
Xylenol Orange tetrasodium salt, Analytical, indicator for metal titration, CAS Number: 3618-43-7, Synonym: 3, 3aE raised to 2 -Bis[N, N-bis(carboxymethyl)aminomethyl]-o-cresolsulfonephthalein tetrasodium salt, Complexometric Reagent, Size: 5G
Supplier:
BeanTown Chemical
Description:
CAS: 111-46-6; EC No: 203-872-2; MDL No: MFCD00002882; RTECS: ID5950000
Liquid; Linear Formula: (HOCH2CH2)2O; Molecular Formula: C4H10O3; MW: 106.12
Melting Point: -10°; Boiling Point: 245°; Flash point: 143°C (289°F)
Density (g/mL): 1.118; Refractive Index: 1.447
Hygroscopic
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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