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2-Cyano-3-(4-methylphenyl)acrylic+acid
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2-Cyano-3-(4-methylphenyl)acrylic+acid
Supplier:
TCI America
Description:
3-Fluoro-5-(trifluoromethyl)benzonitrile, Purity: >98.0%(GC), CAS Number: 149793-69-1, Molecular Formula: C8H3F4N, Molecular Weight: 189.11, Physical state: Liquid, Form: Clear, Colour: Colorless - Almost colorless, Size: 25G
Supplier:
Adipogen
Description:
Inhibitor of pan-Trk activity (IC(50) = 8 and 12nM for TrkA and TrkB). Shown to target Trk (tropomyosin receptor kinase) ATP binding cleft and an immediately adjacent hydrophobic pocket. Preferentially arrests the proliferation of Ba/F3 cells fused with Tel-TrkA, Tel-TrkB and Tel-TrkC (IC(50) = 11, 9 and 7nM, respectively) and in Ba/F3 and RIE cells expressing both TrkA and NGF (IC(50) = 42 and 17nM, respectively) over Mo7e-c-Kit and Rat-A10-PDGFR (IC(50) = 1 and 0.5µM) and Ba/F3-Tel-KDR and wt-Ba/F3 cells (IC(50) = 3.0 and 5.6µM). Displays ~100-fold greater selectivity among a panel of 59 closely related kinases and in 33 cellular kinase assays. Weakly active against relevant cytochrome P450 isozymes and hERG channel, and exhibit adequate microsomal stability, pharmacokinetic profile and efficacy in mice and rats. Suppresses tumor growth in a mouse RIE-TrkAmNGF xenograft model (50mg/kg, p.o.).
Supplier:
AMBEED, INC
Description:
2,6-Dimethoxybenzonitrile, Purity: 98%, CAS Number: 16932-49-3, Appearance: White to Yellow to Brown Solid, Storage: Sealed in dry, Room Temperature, Size: 5g
Supplier:
AMBEED, INC
Description:
2,3,4-Trifluorobenzonitrile, Purity: 98%, CAS Number: 143879-80-5, Appearance: Form: liquid/Colour: Colorless - Very pale yellow, Storage: Sealed in dry, 2-8 C, Size: 5g
Supplier:
AMBEED, INC
Description:
3-Chloro-4-methoxybenzonitrile, Purity: 98%, CAS Number: 102151-33-7, Appearance: Solid, Storage: Inert atmosphere, Room Temperature, Size: 25G
Catalog Number:
(TCT0253-5G)
Supplier:
TCI America
Description:
CAS Number: 119-93-7
MDL Number: MFCD00014773
Molecular Formula: C14H16N2
Molecular Weight: 212.30
Purity/Analysis Method: <gt/>98.0% (GC)
Form: Crystal
Color: White
Boiling point (°C): 300
Melting point (°C): 129
Flash Point (°C): 244
Supplier:
BeanTown Chemical
Description:
CAS: 3058-39-7; MDL No: MFCD00051310
UN No: UN3439; Haz Class: 6.1; Packing Group: III
Solid; Molecular Formula: C7H4IN ; MW: 229.02
Melting Point: 124-128°
Light Sensitive
Catalog Number:
(TCD2870-25G)
Supplier:
TCI America
Description:
CAS Number: 2024-83-1
MDL Number: MFCD00001802 Molecular Formula: C9H9NO2 Molecular Weight: 163.18 Purity/Analysis Method: >98.0% (GC) Form: Crystal Melting point (°C): 69
Supplier:
AMBEED, INC
Description:
3,4-Dichlorobenzonitrile, Purity: 97%, CAS Number: 6574-99-8, Appearance: Powder or crystals, Storage: Sealed in dry, Room Temperature, Size: 25g
Supplier:
AMBEED, INC
Description:
3,5-Difluoro-4-hydroxybenzonitrile, Purity: 96%, CAS number: 2967-54-6, Appearance: Yellow to Brown Solid, Storage: Sealed in dry, 2-8C, Size: 1G
Supplier:
BeanTown Chemical
Description:
CAS: 611-20-1; EC No: 210-259-3; MDL No: MFCD00002145
Solid; Molecular Formula: C7H5NO; MW: 119.12
Melting Point: 92-95°; Boiling Point: 149°/14 mmHg
Catalog Number:
(77273-932)
Supplier:
AMBEED, INC
Description:
3-Ethoxybenzonitrile, Purity: 98+%, CAS Number: 25117-75-3, Appearance: Solid or Semi-solid or liquid or lump, Storage: Sealed in dry, Room Temperature, Size: 5g
Supplier:
Ricca Chemical
Description:
Xylenol orange indicator 0.2% (w/v) in alcohol
Supplier:
AMBEED, INC
Description:
2,3-Difluoro-6-methoxybenzonitrile, Purity: 98%, CAS Number: 221202-34-2, Appearance: Solid, Storage: Sealed in dry, Room Temperature, Size: 250mg
Supplier:
Adipogen
Description:
The BCR-ABL oncogene triggers intracellular signaling, activating multiple transduction cascades, promoting the growth, proliferation and survival of hematopoietic cells. BCR-ABL plays a role in defective DNA repair, alteration of cellular adhesion and inhibition of apoptosis. Degregulated BCR-ABL tyrosine kinase activity is the molecular marker for CML. Inhibiting BCR-ABL tyrosine kinase activity leads to the induction of apoptosis and inhibits cellular proliferation in vitro and there are various BCR-ABL isoforms with differing activity levels as well. Dasatinib (BMS-354825, Sprycel®) is a potent multi-target kinase inhibitor of BCR-ABL. Dasatiinib performs better against ABL kinase than earlier drugs such as imatinib, and Dasatinib also is effective against SRC family of kinases, and other receptor kinases such as EPHA2, PDGFR, and c-Kit. Dasatinib's inhibiting potential against Src family kinase members is greater (IC(50) 0.5nM) than its inhibitory activity against ABL (1nM).
Supplier:
AMBEED, INC
Description:
2,4-Dimethylbenzonitrile, Purity: 98%, CAS Number: 21789-36-6, Appearance: Form: Liquid - Crystal - Lump, Storage: Sealed in dry, Room Temperature, Size: 250mg
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