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Catalog Number:
(75791-394)
Supplier:
Prosci
Description:
Mouse myeloid cell surface antigen CD33(CD33) is a member of the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD33 contains one Ig-like C2-type domain and one Ig-like V-type domain. CD33 is a putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. CD33 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, CD33 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 induces apoptosis in acute myeloid leukemia. CD33 is becoming increasingly important as a target of antibody-mediated therapy in acute myeloid leukaemia (AML).
Supplier:
AMBEED, INC
Description:
L-Glutamic acid diethyl ester hydrochloride 95%
Catalog Number:
(75789-620)
Supplier:
Prosci
Description:
Hepatocyte Cell Adhesion Molecule (HEPACAM) is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. HEPACAM includes a signal sequence (amino acid 1-33), an extracellular region (amino acid 34-240) with one Ig-like C2-type domain and one Ig-like V-type domain, a transmembrane segment (amino acid 241-261), and a cytoplasmic domain (amino acid 262 - 416). The cytoplasmic domain plays an important role in regulation of cell-matrix adhesion and cell motility. HEPACAM acts as a homodimer and dimer formation occurs predominantly through cis interactions on the cell surface. HEPACAM is involved in cell motility and cell-matrix interactions. The expression of this gene is down-regulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene.
Catalog Number:
(101442-964)
Supplier:
Southern Biotechnology
Description:
CD33 is a 67 kDa type I transmembrane glycoprotein and a member of the sialoadhesin family of cell surface receptors. It is absent from pluripotent stem cells but appears on myelomonocytic precursors after CD34. It then continues to be expressed on both the myeloid and monocyte lineages. While it has been reported that CD33 can function as a sialic acid-dependent cell adhesion molecule, cells expressing CD33 require desialylation before they can bind cells bearing the appropriate sialoglycoconjugates. This suggests that inhibitory cis interactions may regulate or block any adhesion function.
Supplier:
Matrix Scientific
Description:
MF=C5H10CLNO3 MW=167.59 CAS=5451-09-2 MDL=MFCD00012869 10G
Supplier:
AMBEED, INC
Description:
6-Methylpiperidine-2-carboxylic acid hydrochloride, Purity: 97%, CAS Number: 117928-49-1, Appearance: Solid, Storage: Inert atmosphere, Room Temperature, Size: 5G
Supplier:
AMBEED, INC
Description:
3-(Aminomethyl)benzoic acid hydrochloride, Purity: 97%, CAS Number: 876-03-9, Appearance: Form: solid, Storage: Inert atmosphere, 2-8 C, Size: 5g
Supplier:
AMBEED, INC
Description:
4-(Methylamino)butanoic acid hydrochloride 97%
Supplier:
AMBEED, INC
Description:
Piperidin-4-ylboronic acid hydrochloride, Purity: 98%, CAS Number: 2306405-20-7, Appearance: Solid, Storage: Inert atmosphere, 2-8C, Size: 5G
Supplier:
AMBEED, INC
Description:
2-(Pyridin-3-yl)acetic acid hydrochloride 95%
Supplier:
AMBEED, INC
Description:
1-Methylpyrrolidine-2-carboxylic acid hydrochloride 97%
Catalog Number:
(77406-442)
Supplier:
APOLLO SCIENTIFIC
Description:
2-Amino-4-cyanobenzeneboronic acid hydrochloride 95%
Supplier:
AMBEED, INC
Description:
(S)-2-Amino-2-cyclohexylacetic acid hydrochloride 97%
Supplier:
AMBEED, INC
Description:
Morpholine-3-carboxylic acid hydrochloride 95%
Catalog Number:
(10354-696)
Supplier:
Bioss
Description:
SIGLEC10 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It preferentially binds to alpha2,3- or 2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. SIGLEC10 interacts with PTPN6/SHP-1 upon phosphorylation. The protein is expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation).
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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