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4-[(4-Methyl-1-piperazinyl)methyl]benzoic+acid+dihydrochloride
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4-[(4-Methyl-1-piperazinyl)methyl]benzoic+acid+dihydrochloride
Catalog Number:
(10289-300)
Supplier:
Bioss
Description:
Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines, thereby repressing expression of the target gene. Dnmt3L (DNA (cytosine-5)-methyltransferase 3-like) is a 387 amino acid protein that contains one ADD-type zinc finger and is a member of the Dnmt family. Localized to the nucleus and expressed at lows levels in thymus, testis and ovary, Dnmt3L does not exhibit DNA methyltransferase activity, but is able to stimulate de novo methylation by Dnmt3 and is thought to play a key role in the establishment of genomic imprints. Additionally, Dnmt3L interacts with histone deacetylase 1 (HDAC1) and, through this interaction, mediates transcriptional repression. Multiple isoforms of Dnmt3L exist due to alternative splicing events.
Catalog Number:
(10289-284)
Supplier:
Bioss
Description:
Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines, thereby repressing expression of the target gene. Dnmt3L (DNA (cytosine-5)-methyltransferase 3-like) is a 387 amino acid protein that contains one ADD-type zinc finger and is a member of the Dnmt family. Localized to the nucleus and expressed at lows levels in thymus, testis and ovary, Dnmt3L does not exhibit DNA methyltransferase activity, but is able to stimulate de novo methylation by Dnmt3 and is thought to play a key role in the establishment of genomic imprints. Additionally, Dnmt3L interacts with histone deacetylase 1 (HDAC1) and, through this interaction, mediates transcriptional repression. Multiple isoforms of Dnmt3L exist due to alternative splicing events.
Catalog Number:
(76009-636)
Supplier:
Prosci
Description:
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.
Supplier:
Matrix Scientific
Description:
MF=C13H10O4S MW=262.29 CAS=5361-54-6 MDL=MFCD00568775 250MG
Catalog Number:
(102663-686)
Supplier:
Matrix Scientific
Description:
4'-Fluorobiphenyl-4-carboxylic acid
Catalog Number:
(82022-426)
Supplier:
G-Biosciences
Description:
Ideal for enzyme-antibody crosslinking.
Supplier:
MP Biomedicals
Description:
Dimethyl sulfoxide is a dipolar, aprotic solvent. Has been shown to accelerate strand renaturation (1-10% concentration) and is believed to give the nucleic acid thermal stability against depurination. By heating the solid form to approximately 30 °C, the product can be melted without harming it's stability.
Catalog Number:
(101842-928)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 037222-500MG , MDL Number: MFCD11156565
Catalog Number:
(IC19011050)
Supplier:
MP Biomedicals
Description:
N-Lauroylsarcosine is an anionic detergent.
Catalog Number:
(101807-280)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 019002-500MG , MDL Number: MFCD06375934
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 041672-1G , MDL Number: MFCD01619006
Supplier:
Thermo Scientific Chemicals
Description:
N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester, 95%
Supplier:
AMBEED, INC
Description:
4-Nitro-2-(trifluoromethyl)benzoic acid, Purity: 98%, CAS number: 320-37-6, Appearance: Form: Crystal - Powder / Colour: White - Yellow - Green, Storage: Sealed in dry, Room Temperature, Size: 10G
Supplier:
Strem Chemicals Inc
Description:
Boronic Acid and Ester
Catalog Number:
(76079-524)
Supplier:
Bioss
Description:
This gene encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone.
Catalog Number:
(101929-416)
Supplier:
Matrix Scientific
Description:
MF=C7H14N2O2 MW=158.20 MDL=MFCD00154385 500Mg
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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