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5-(3,5-Difluorophenyl)thiazol-2-amine
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5-(3,5-Difluorophenyl)thiazol-2-amine
Supplier:
AOB CHEM USA
Description:
2,3-Difluorocinnamic acid ≥95%
Catalog Number:
(101805-966)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 018337-5G , MDL Number: MFCD00142822
Supplier:
TCI America
Description:
4-Ethoxy-2,3-difluorophenylboronic Acid, CAS Number: 212386-71-5, Molecular Formula: C8H9BF2O3, Molecular Weight: 201.96, Synonyms: 4-Ethoxy-2,3-difluorobenzeneboronic Acid (contains varying amounts of Anhydride), Size: 1G
Supplier:
Matrix Scientific
Description:
MF=C9H8F2O MW=170.16 Cas=29112-90-1 MDL=MFCD00015509 1G
Supplier:
AMBEED, INC
Description:
2,4-Difluorobenzyl alcohol 96%
Supplier:
Adipogen
Description:
The kinases called p38 MAP kinases (MAPKs) are intracellular, soluble serine-threonine kinases which belong to a large family of proteins that include the extracellular regulated kinases (ERKs) and c-Jun N-terminal kinases (JNKs). So far four p38 isoforms have been identified, namely p38alpha, p38beta, p38gamma and p38delta, a.k.a. p38-alpha (MAPK14), -beta (MAPK11), -gamma (MAPK12 / ERK6), and -delta (MAPK13 / SAPK4). The ubiquitously expressed s p38alpha has been the most extensively studied and is believed to be the most physiologically relevant in the regulation of the inflammatory response. The role of the three other isoforms is not currently well understood, however their primary sites of expression are known. Similar to p38alpha, p38beta is also ubiquitously expressed, while p38gamma is expressed predominately in skeletal muscle and p38delta is expressed primarily in the lung, kidney, testis, small intestine and pancreas. The small molecule inhibitor VX-702 is a potent p38 kinase family inhibitor that has been studied for its effects on inflammation and the inflammatory response. VX-702 dose-dependently inhibited the production o IL-6, IL-1beta and TNFalpha (IC(50) = 59, 122 and 99ng/ml, respectively), and in anti-platelet aggregation assays, pre-incubation of platelets with VX-702 (1µM)completely or partially inhibited platelet agonist induced p38 activation (IC(50) = 4 to 20nM). More recently VX-702 has been studied as a potential treatment for rheumatoid arthritis (RA). VX-702 appears to be most effective against MAPK14, followed by MAPK11 and the remaining members of the family, however exact in vitro IC(50) values have not been published. However a large amount of data is available for in vitro growth inhibition assays where VX-702 exhibits poptent activity, having low IC(50) values beginning at ~16nM and ending at < 400µM for the numerous cell lines tested.
Supplier:
Adipogen
Description:
PLX4032 (Vemurafenib, RG7204, Zelboraf, RO5185426) is a novel and potent inhibitor of B-RafV600E with an IC(50) of 31nM.
Supplier:
Matrix Scientific
Description:
MF=C7H6F2O MW=144.12 Cas=85118-05-4 MDL=MFCD00010628 5G
Catalog Number:
(102519-600)
Supplier:
Matrix Scientific
Description:
MF=C14H11F2NO2 MW=263.25 CAS=112434-18-1 MDL=MFCD21648243 5G
Supplier:
Thermo Scientific Chemicals
Description:
Potassium 2,4-difluorophenyltrifluoroborate, 95%
Supplier:
AMBEED, INC
Description:
5-Bromo-2,3-difluorobenzeneboronic acid, pinacol ester 96%
Supplier:
AOB CHEM USA
Description:
4-Ethoxy-2,6-difluorophenylboronic acid ≥97%
Catalog Number:
(76872-776)
Supplier:
AMBEED, INC
Description:
4-Butoxy-2,3-difluorophenylboronic acid 98%
Supplier:
AMBEED, INC
Description:
Dicyclopentadienylbis[2,6-difluoro-3-(1-pyrrolyl)phenyl]titanium, Purity: 98%, CAS Number: 125051-32-3, Appearance: Solid, Storage: Inert atmosphere, 2-8 C, Size: 25g
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
2-(Trimethylsilyl)thiazole 96%
Supplier:
AOB CHEM USA
Description:
4-Benzyloxy-2,3-difluorophenylboronic acid ≥97%
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
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