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5-(3-Isopropoxyphenyl)thiazol-2-amine
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5-(3-Isopropoxyphenyl)thiazol-2-amine
Catalog Number:
(101920-308)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 060597-500MG , MDL Number: MFCD16039338
Supplier:
AMBEED, INC
Description:
8-Amino-2-methylquinoline 98%
Catalog Number:
(101931-372)
Supplier:
Matrix Scientific
Description:
MF=C15H11Clfn5 MW=315.74 MDL=MFCD13817052 ,500Mg
Catalog Number:
(101934-200)
Supplier:
Matrix Scientific
Description:
MF=C14H17N3O MW=243.31 ,250Mg
Supplier:
Adipogen
Description:
Aurora kinases constitute a family of serine-threonine kinases that are strongly associated with cancer. Aurora A and B are essential in mitosis. Perturbation of their activity leads to multiple defects in mitosis including aberrant centrosome duplication, misalignment of chromosomes, inhibition of cytokinesis, and disruption of the spindle checkpoint. The role of Aurora C is unclear; however, Aurora C can complement Aurora B kinase activity in mitosis. SNS-314 is an ATP-competitive, selective, and potent nanomolar inhibitor of aurora kinases in vitro. A cocrystal structure of SNS-314 with Aurora A confirms that SNS-314 engages the purine-binding pocket of Aurora. SNS-314 inhibits cellular proliferation in the HCT116 colorectal carcinoma cell line with an EC50 of ~5nM. Analysis of DNA content and indirect immunofluoresence demonstrates that SNS-314 induces defects in cytokinesis and spindle checkpoint that are consistent with Aurora kinase inhibition. Phosphorylation of Histone H3 on serine 10, a known Aurora B cellular target, is inhibited with an EC50 of ~9nM following treatment of cells with SNS-314. Administration of SNS-314 to HCT116 tumor bearing mice potently suppresses tumor growth. Analysis of SNS-314 treated tumors confirms that the anti-tumor activity is consistent with Aurora kinase inhibition. SNS-314 is a potent small-molecule inhibitor of Aurora kinase that is being developed as a novel anti-cancer therapeutic agent.
Supplier:
Matrix Scientific
Description:
MF=C9H7CLN2 MW=178.62 CAS=342899-38-1 MDL=MFCD08235154 1G
Catalog Number:
(101930-792)
Supplier:
Matrix Scientific
Description:
MF=C13H19N5 MW=245.33 MDL=MFCD19103531 ,500Mg
Supplier:
Matrix Scientific
Description:
(2-{[1-Ethyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]methoxy}ethyl)amine hydrochloride
Supplier:
AMBEED, INC
Description:
(11bR)-N-Benzyl-N-methyldinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine, Purity: 98% +99%ee, CAS Number: 1221902-06-2, Appearance: White to off-white powder or crystals, Storage: Inert atmosphere, 2-8C, Size: 250MG
Catalog Number:
(102523-776)
Supplier:
Matrix Scientific
Description:
MF=C8H11BRN4O MW=259.11 CAS=117719-17-2 MDL=MFCD08056165 10G
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 055443-5G , MDL Number: MFCD16622770
Supplier:
AOB CHEM USA
Description:
5-p-Tolylpyridin-2-ylamine ≥97%
Supplier:
AMBEED, INC
Description:
6-Benzyl-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-amine, Purity: 98%, CAS number: 1256353-14-6, Appearance: Solid, Storage: Keep in dark place, Sealed in dry, 2-8C, Size: 1G
Catalog Number:
(101836-722)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 033970-500MG , MDL Number: MFCD03419812
Catalog Number:
(77014-444)
Supplier:
AMBEED, INC
Description:
[1,2,4]Triazolo[4,3-a]pyridin-7-amine hydrochloride 95%
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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The original product is no longer available. The replacement shown is available.
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