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Boc-N-Me-D-Tyr-OH\u00B7DCHA
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Boc-N-Me-D-Tyr-OH\u00B7DCHA
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 042256-1G , MDL Number: MFCD01318372
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 042239-1G , MDL Number: MFCD01076279
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 042213-1G , MDL Number: MFCD01860913
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 042243-1G , MDL Number: MFCD01861081
Supplier:
Thermo Scientific Chemicals
Description:
Grade: 98+. Melting Point C218*(dec). Boiling Point C: NA. C9H11NO2. 17136-36-6.
Supplier:
AFG BIOSCIENCE LLC
Description:
Fmoc-L-Thr (Gal β(1-3)GalNAc)-OH, peracetate ≥95%
Supplier:
TCI America
Description:
NA,NE-Bis[(9H-fluoren-9-ylmethoxy)carbonyl]-L-lysine, Purity: >98.0%(HPLC)(T), Cas no. 78081-87-5, Molecular formula: C36H34N2O6, Form: Crystal - Powder, Colour: Almost white, Synonyms: NA,NE-Di-Fmoc-L-lysine, Fmoc-Lys(Fmoc)-OH, Size: 5G
Supplier:
Matrix Scientific
Description:
MF=C10H13BRN2O2 MW=273.14 CAS=885275-14-9 MDL=MFCD05664029 5G
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 041300-250MG , MDL Number: MFCD09750592
Supplier:
Thermo Scientific Chemicals
Description:
5g CAS: 334999-32-5, MDL: MFCD03787929
Catalog Number:
(10254-128)
Supplier:
Bioss
Description:
c-Src tyrosine kinase plays a critical role in signal transduction downstream of growth factor receptors, integrins and G protein-coupled receptors. We used stable isotope labeling with amino acids in cell culture (SILAC) approach to identify additional substrates of c-Src tyrosine kinase in human embryonic kidney 293T cells. We have identified 10 known substrates and interactors of c-Src and Src family kinases along with 26 novel substrates. We have experimentally validated 4 of the novel proteins (NICE-4, RNA binding motif 10, FUSE-binding protein 1 and TRK-fused gene) as direct substrates of c-Src using in vitro kinase assays and cotransfection experiments. Significantly, using a c-Src specific inhibitor, we were also able to implicate 3 novel substrates (RNA binding motif 10, EWS1 and Bcl-2 associated transcription factor) in PDGF signaling. Finally, to identify the exact tyrosine residues that are phosphorylated by c-Src on the novel c-Src substrates, we designed custom peptide microarrays containing all possible tyrosine-containing peptides (312 unique peptides) and their mutant counterparts containing a Tyr -->Phe substitution from 14 of the identified substrates. Using this platform, we identified 34 peptides that are phosphorylated by c-Src. We have demonstrated that SILAC-based quantitative proteomics approach is suitable for identification of substrates of nonreceptor tyrosine kinases and can be coupled with peptide microarrays for high-throughput identification of substrate phosphopeptides.
Supplier:
VWR
Description:
Packaged at pH 6.6, this mixture is provided with a supplemental alkaline buffer that
allows the researcher to easily increase the pH to 7.9 for DNA purification. When mixed with Chloroform:Isoamyl Alcohol (24:1), it makes an optimized reagent for DNA purification. Doubly distilled, high purity phenol packaged under nitrogen. Safer, easier alternative to crystalline phenol.
Catalog Number:
(102597-364)
Catalog Number:
(76724-964)
Supplier:
AMBEED, INC
Description:
cis-N-Boc-4-cyano-L-proline methyl ester 98%
Supplier:
AMBEED, INC
Description:
Fmoc-Lys(Mtt)-OH, Purity: 98%, CAS number: 167393-62-6, Appearance: Form: Crystal - Powder / Colour: White - Pale-yellow, Storage: Sealed in dry, Store in freezer, under -20C, Size: 25G
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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