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4,4\'-Methylenebis(2,6-diethylaniline)
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4,4\'-Methylenebis(2,6-diethylaniline)
Supplier:
TCI America
Description:
CAS Number: 96478-09-0
MDL Number: MFCD00213348 Molecular Formula: C18H17N3O3 Molecular Weight: 323.35 Purity/Analysis Method: >98.0% (GC) Form: Crystal Melting point (°C): 98
Supplier:
Adipogen
Description:
Potent, selective and orally available NLRP3 inflammasome inhibitor. Blocks the release of IL-1beta in macrophages primed with LPS and activated with ATP or nigericin, but it does not inhibit NLRP1, NLRC4, AIM2, TLR2 signaling or priming of NLRP3. Prevents oligomerization of ASC in cells stimulated with LPS and nigericin. Active in vivo, blocking the production of IL-1beta and enhancing survival in mouse models of multiple sclerosis and cryopyrin-associated periodic syndrome (CAPS). Also active in ex vivo samples from individuals with Muckle-Wells syndrome. Potential therapeutic agent for NLRP3-associated syndromes, including autoinflammatory and autoimmune diseases.
Supplier:
MilliporeSigma
Description:
N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride for synthesis, CAS number 25952-53-8, Chemical formula C8H17N3*HCl 25g
Supplier:
Chem Impex International
Description:
A carbodiimide coupling reagent that generates a urea by-product which can be easily removed from the reaction media by extraction with water
Supplier:
G-Biosciences
Description:
EDC is a heterobifunctional, water-soluble, zero-length carbodiimide crosslinker that is used to couple carboxyl groups to primary amines. EDC activates carboxyl groups first and forms amine reactive O-acylisourea imtermediate that spontaneously reacts with primary amines to form an amide bond and isourea by-product.
Supplier:
Spectrum Chemicals
Description:
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Hydrochloride, purity: 98 %, CAS number: 25952-53-8, Molecular Formula: C8H17N3.HCl, Molecular weight: 191.71, Form: Solid, synonyms: monohydrochloride, EDAP, size: 1 g
Catalog Number:
(101805-826)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 018285-5G , MDL Number: MFCD00234183
Catalog Number:
(IC15798283)
Supplier:
MP Biomedicals
Description:
Ethylene Glycol bis(Succinic Acid N-Hydroxysuccinimide Ester) is a homobifunctional, cleavable cross-linking reagent. It is typically, coupled to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). The linkage provides a 12-atom spacer.
Catalog Number:
(102987-460)
Supplier:
Adipogen
Description:
Potent and selective inhibitor of cyclin dependent kinases CDK1, CDK2, CDK5, CDK7 and CDK9. Pyridoxal kinase (PDXK) inhibitor. Triggers cell apoptotic cell death. Down-regulates Mcl-1 and MYCN. Anticancer compound. Kills chronic lymphocytic leukemia (LLC) cells and slows tumor growth in mouse xenografts. Inhibits cysts formation in culture and in polycystic kidney disease (PKD) mouse models. Potential anti-inflammatory compound that can influence the resolution of inflammation. Potential antidiabetic compound. Shown to protect pancreatic beta-cells from glucotoxicity and increase insulin secretion. Shows antiviral properties. Neuroprotective in brain trauma. Has positive effects on Timothy syndrome cells. Used for cloning of mammals by synchronization of nucleus donor cells. Provides neuroprotection in experimental traumatic brain injury.
Supplier:
ALADDIN SCIENTIFIC
Description:
4-Amino-nicotinic acid is a white to light yellow and faint beige to light beige and faint brown to light brown powder or crystals.4-Aminonicotinic acid has been used in the preparation of 2-methyl-pyrido-oxazine.
Supplier:
Adipogen
Description:
Aurora kinases constitute a family of serine-threonine kinases that are strongly associated with cancer. Aurora A and B are essential in mitosis. Perturbation of their activity leads to multiple defects in mitosis including aberrant centrosome duplication, misalignment of chromosomes, inhibition of cytokinesis, and disruption of the spindle checkpoint. The role of Aurora C is unclear; however, Aurora C can complement Aurora B kinase activity in mitosis. SNS-314 is an ATP-competitive, selective, and potent nanomolar inhibitor of aurora kinases in vitro. A cocrystal structure of SNS-314 with Aurora A confirms that SNS-314 engages the purine-binding pocket of Aurora. SNS-314 inhibits cellular proliferation in the HCT116 colorectal carcinoma cell line with an EC50 of ~5nM. Analysis of DNA content and indirect immunofluoresence demonstrates that SNS-314 induces defects in cytokinesis and spindle checkpoint that are consistent with Aurora kinase inhibition. Phosphorylation of Histone H3 on serine 10, a known Aurora B cellular target, is inhibited with an EC50 of ~9nM following treatment of cells with SNS-314. Administration of SNS-314 to HCT116 tumor bearing mice potently suppresses tumor growth. Analysis of SNS-314 treated tumors confirms that the anti-tumor activity is consistent with Aurora kinase inhibition. SNS-314 is a potent small-molecule inhibitor of Aurora kinase that is being developed as a novel anti-cancer therapeutic agent.
Supplier:
Invitrogen
Description:
Thermo Scientific Pierce EDC is a carboxyl- and amine-reactive zero-length crosslinker. EDC reacts with a carboxyl group first and forms an amine-reactive O-acylisourea intermediate that quickly reacts with an amino group to form an amide bond with release of an isourea by-product. The intermediate is unstable in aqueous solutions and so two-step conjugation procedures rely on N-hydroxysuccinimide (NHS) for stabilization. Failure to react with an amine will result in hydrolysis of the intermediate, regeneration of the carboxyl, and release of an N-substituted urea. A side reaction is the formation of an N-acylurea, which is usually restricted to carboxyls located in hydrophobic regions of proteins.
Supplier:
AMBEED, INC
Description:
2-Amino-2-(hydroxymethyl)propane-1,3-diol acetate salt, Purity: 98%, CAS Number: 6850-28-8, Appearance: Form: Crystal - Powder / Colour: White - Almost white, Storage: Inert atmosphere, Room Temperature, Size: 100G
Catalog Number:
(103523-940)
Supplier:
Invitrogen
Description:
Thermo Scientific Pierce EDC is a carboxyl- and amine-reactive zero-length crosslinker. EDC reacts with a carboxyl group first and forms an amine-reactive O-acylisourea intermediate that quickly reacts with an amino group to form an amide bond with release of an isourea by-product. The intermediate is unstable in aqueous solutions and so two-step conjugation procedures rely on N-hydroxysuccinimide (NHS) for stabilization. Failure to react with an amine will result in hydrolysis of the intermediate, regeneration of the carboxyl, and release of an N-substituted urea. A side reaction is the formation of an N-acylurea, which is usually restricted to carboxyls located in hydrophobic regions of proteins.
Supplier:
Thermo Scientific Chemicals
Description:
Manufacturing of Cd salts, photographic emulsions, laboratory reagent, coloring glass
Supplier:
MP Biomedicals
Description:
Metronidazole ia an antiprotozoal (Trichomonas), a limited spectrum antibiotic that actively deters the growth of protozoa, anaerobic gram-positive, and anaerobic gram-negative bacteria.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
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