Text Search >
GSK-J4+hydrochloride
Print…
You Searched For:
15,680 results were found
GSK-J4+hydrochloride
Supplier:
AMBEED, INC
Description:
GSK-2982772 ≥99%
Supplier:
Enzo Life Sciences
Description:
Inibitor of phosphoinositide-dependent kinase 1 and GSK
Supplier:
AMBEED, INC
Description:
6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine, Purity: 98%, CAS Number: 1346547-00-9, Appearance: Form: solid, Storage: Keep in dark place, Inert atmosphere, 2-8 C, Size: 25mg
Catalog Number:
(220009-336)
Supplier:
R&D Systems
Description:
The Recombinant Human Active GSK-3 beta Protein from R&D Systems is derived from Sf 9 (baculovirus). The Recombinant Human Active GSK-3 beta Protein has been validated for the following applications: Bioactivity.
Catalog Number:
(103275-846)
Supplier:
Novus Biologicals
Description:
The GSK-3 alpha Antibody from Novus Biologicals is a rabbit polyclonal antibody to GSK-3 alpha. This antibody reacts with human. The GSK-3 alpha Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin.
Catalog Number:
(103280-298)
Supplier:
Novus Biologicals
Description:
The GSK-3 beta Antibody from Novus Biologicals is a rabbit polyclonal antibody to GSK-3 beta. This antibody reacts with human, mouse, rat. The GSK-3 beta Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.
Catalog Number:
(89161-016)
Supplier:
Enzo Life Sciences
Description:
This peptide sequence, RRRAAEELDSRAGpSPQL, corresponds to the sequence of the epsilon subunit of elF2B surrounding Ser540, a target of GSK-3 (glycogen synthase kinase 3) phosphorylation, with the addition of a phosphoserine in the 4 position. This phosphoserine allows for more efficient phosphorylation of the second serine in the peptide(Km=49 µM for GSK-3ß, 83 µM for GSK-3alpha). Useful in phosphocellulose GSK-3alpha and -ß assays.
Catalog Number:
(89141-424)
Supplier:
Enzo Life Sciences
Description:
Glycogen Synthase Kinase 3β (GSK-3β) is a unique serine/threonine kinase that is inactivated by phosphorylation. In response to insulin binding, PKB/AKT phosphorylates GSK-3β on serine 9, which prevents GSK-3β from phosphorylating glycogen synthase. Unphosphorylated glycogen synthase is active and able to synthesize glycogen. GSK-3β is also unique in that it requires a substrate that has been phosphorylated by a distinct kinase before it can phosphorylate the substrate. This phosphate priming mechanism explains why phosphorylation of serine 9 inactivates GSK-3β. The phosphorylated serine binds to the GSK-3β priming phosphate position and prevents binding of alternative substrates. In addition to insulin signaling, GSK-3β participates in the Wnt signaling pathway, where it forms a complex with axin, beta-catenin and adenomatous polyposis coli (APC) protein. In the presence of Wnts, GSK-3β is unable to phosphorylate beta-catenin, which leads to stabilization of beta-catenin. The Wnt pathway inactivates GSK-3β via the proteins, Dishevelled and FRAT, which disrupt the interaction of GSK-3β with axin, beta-catenin, and APC. Clinically, there is considerable interest in GSK-3β inhibitors because they may mimic the effect of insulin or reduce the hyperphosphorylation of Tau that is observed in Alzheimer's Disease.
Supplier:
AMBEED, INC
Description:
3-Isopropyl-5-(4-(((6-(4-(methylsulfonyl)phenyl)pyridin-3-yl)oxy)methyl)piperidin-1-yl)-1,2,4-oxadiazole, Purity: 98+%, CAS number: 1032823-75-8, Appearance: White to off-white solid, Storage: Sealed in dry, Room Temperature, Size: 1MG
Supplier:
Enzo Life Sciences
Description:
Glycogen Synthase Kinase 3β (GSK-3β) is a unique serine/threonine kinase that is inactivated by phosphorylation. In response to insulin binding, PKB/AKT phosphorylates GSK-3β on serine 9, which prevents GSK-3β from phosphorylating glycogen synthase. Unphosphorylated glycogen synthase is active and able to synthesize glycogen. GSK-3β is also unique in that it requires a substrate that has been phosphorylated by a distinct kinase before it can phosphorylate the substrate. This phosphate priming mechanism explains why phosphorylation of serine 9 inactivates GSK-3β. The phosphorylated serine binds to the GSK-3β priming phosphate position and prevents binding of alternative substrates. In addition to insulin signaling, GSK-3β participates in the Wnt signaling pathway, where it forms a complex with axin, beta-catenin and adenomatous polyposis coli (APC) protein. In the presence of Wnts, GSK-3β is unable to phosphorylate beta-catenin, which leads to stabilization of beta-catenin. The Wnt pathway inactivates GSK-3β via the proteins, Dishevelled and FRAT, which disrupt the interaction of GSK-3β with axin, beta-catenin, and APC. Clinically, there is considerable interest in GSK-3β inhibitors because they may mimic the effect of insulin or reduce the hyperphosphorylation of Tau that is observed in Alzheimer's Disease.
Catalog Number:
(77621-562)
Supplier:
AMBEED, INC
Description:
2-(2-(Cyclopropanecarboxamido)pyridin-4-yl)-4-methoxythiazole-5-carboxamide ≥98%
Supplier:
AMBEED, INC
Description:
GSK180736A 97%
Supplier:
AMBEED, INC
Description:
4-Chloro-N-(2-((5-(trifluoromethyl)pyridin-2-yl)sulfonyl)ethyl)benzamide, Purity: 98%, CAS Number: 188591-46-0, Appearance: Form: solid, Storage: Sealed in dry, 2-8 C, Size: 10mg
Supplier:
Thermo Scientific Chemicals
Description:
6-Bromoindirubin-3'-oxime, 97%. Solid.
Supplier:
AMBEED, INC
Description:
Methyl 3-(N-(2-methoxy-4-(phenylamino)phenyl)sulfamoyl)thiophene-2-carboxylate, Purity: 98%, CAS Number: 1014691-61-2, Appearance: Form: powder, Storage: Keep in dark place, Sealed in dry, 2-8 C, Size: 10mg
Supplier:
AMBEED, INC
Description:
N-((S)-1-Amino-3-(3-fluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxamide, Purity: 99+%, CAS Number: 1047644-62-1, Appearance: White to off-white powder, Storage: Keep in dark place, Inert atmosphere, Store in freezer, under -20 C, Size: 1g
Inquire for Price
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
|
|||||||||
List View
