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IKK-2
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IKK-2
Catalog Number:
(76234-936)
Supplier:
Rockland Immunochemical
Description:
Anti-NEMO antibody was designed, produced, and validated as part of the Joy Cappel Young Investigator Award (JCYIA). Anti-NEMO antibody detects recombinant and endogenous NEMO. NEMO, the regulatory subunit of the IKK core complex, phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Nemo is also considered to be a mediator for TAX activation of NF-kappa-B and may be implicated in NF-kappa-B-mediated protection from cytokine toxicity. NEMO is essential for viral activation of IRF3 and involved in TLR3- and IFIH1-mediated antiviral innate response. The innate antivaral response from NEMO requires 'Lys-27'-linked polyubiquitination. Anti-NEMO is ideal for researchers interested in Immunology and Cancer research.
Supplier:
Cayman Chemical Company
Description:
SC-514, Purity >/=98%, CAS 354812-17-2, MF: C9H8N2OS2, MW: 224.3, Synonyms: 4-amino-[2,3'-bithiophene]-5-carboxamide, selective and reversible inhibitor of IKB kinase 2, Formulation: A crystalline solid, Size: 10mg
Supplier:
ANTIBODIES.COM LLC
Description:
Rabbit polyclonal antibody to IKK beta (phospho Tyr199) for WB with samples derived from Human, Mouse and Rat.
Catalog Number:
(76171-208)
Supplier:
Boster Biological Technology
Description:
Rabbit IgG polyclonal antibody for NF-kappa-B essential modulator(IKBKG) detection. Tested with WB in Human;Mouse;Rat.
Catalog Number:
(ABCA_AB205788-100U)
Supplier:
ABCAM INC.
Description:
Anti-IKK gamma/NEMO Rabbit Monoclonal Antibody [clone: EPR16629] (Alexa Fluor® 647)
Catalog Number:
(10432-842)
Supplier:
Bioss
Description:
Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK.
Supplier:
ANTIBODIES.COM LLC
Description:
Rabbit polyclonal antibody to IKK gamma / NEMO (phospho Ser376) for WB with samples derived from Human, Mouse and Rat.
Catalog Number:
(10346-498)
Supplier:
Bioss
Description:
Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101).
Catalog Number:
(80083-392)
Supplier:
Abgent
Description:
Purified Mouse Monoclonal Antibody (Mab). This antibody was raised using purified His-tagged recombinant full length human IKK alpha. Specificity: H. Concentration: 0.25 mg/ml. Size: 0.1 mg.
Catalog Number:
(102165-696)
Supplier:
Novus Biologicals
Description:
Rabbit Polyclonal IKK beta Antibody. Tested Applications: Western Blot. Tested Reactivity: Human.
Catalog Number:
(102885-628)
Supplier:
R&D Systems
Description:
Human Phospho-IKK alpha (S176/S180) Monoclonal antibody (Clone 829177), Isotype: Rat IgG2A, Application: Western Blot, 100 UG
Catalog Number:
(10802-390)
Supplier:
Rockland Immunochemical
Description:
Nuclear factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-kB associates with IkB proteins in the cell cytoplasm, which inhibit NF-kB activity. IkB is phosphorylated by IkB kinase (IKK) complex that contains IKKa, IKKb, and IKKgamma. A novel molecule that associates with and activates IKK was recently identified and designated CIKS (for connection to IKK and SAPK/JNK) and Act1 (for NF-kB activator 1). CIKS directly interacts with IKKgamma. CIKS/Act1 also activates activating transcription factor (ATF) and activator protein 1 (AP-1) through Jun kinase (JNK). These results indicate that CIKS/Act1 is involved in the inflammation and stress responses. CIKS/Act1 is ubiquitously expressed in human tissues.
Catalog Number:
(ABCA_AB17943-50UL)
Supplier:
ABCAM INC.
Description:
Anti-IKK alpha (phospho S176 + S180) Rabbit Polyclonal Antibody
Catalog Number:
(102110-242)
Supplier:
Novus Biologicals
Description:
Mouse Monoclonal IKK alpha Antibody (14A231). Tested Applications: Western Blot, Immunoprecipitation. Tested Reactivity: Human, Mouse, Primate.
Catalog Number:
(RL100-401-219P)
Supplier:
Rockland Immunochemical
Description:
50uL. Peptide Concentration: 1 mg/mL (by weight). Buffer: 0.01M potassium phosphate, 0.15M sodium chloride, pH 7.2. Stabilizer: None. Sterile filtered liquid.
Catalog Number:
(10749-478)
Supplier:
Prosci
Description:
CIKS Antibody: Nuclear factor kappa B (NF-kappa B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappa B mediates the expression of a great variety of genes in response to extracellular stimuli. NF-kappa B associates with Ikappa B proteins in the cell cytoplasm, which inhibit NF-kappa B activity. Ikappa B is phosphorylated by Ikappa B kinase (IKK) complex that contains IKKalpha , IKKbeta , and IKKgamma;. A novel molecule that associates with and activates IKK was recently identified and designated CIKS (for connection to IKK and SAPK/JNK) and Act1 (for NF-kappa B activator 1). CIKS directly interacts with IKKgamma;. CIKS/Act1 also activates activating transcription factor (ATF) and activator protein 1 (AP-1) through Jun kinase (JNK). These results indicate that CIKS/Act1 is involved in the inflammation and stress responses. CIKS/Act1 is ubiquitously expressed in human tissues.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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