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4,6-Dimethoxy-5-nitropyrimidine
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4,6-Dimethoxy-5-nitropyrimidine
Catalog Number:
(10343-528)
Supplier:
Bioss
Description:
Lymphocyte-activation protein 3 (LAG-3), also known as CD223, belongs to the immunoglobulin superfamily and contains 4 extracellular Ig-like domains. LAG-3 binds to HLA class-II antigens and is involved in lymphocyte activation. It is found on the cell surface of activated NK and T-lymphocytes. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG-3 to CD4.
Supplier:
BeanTown Chemical
Description:
CAS: 10048-95-0; EC No: 231-902-4; MDL No: MFCD00149179; RTECS: CG0900000
UN No: UN1685; Haz Class: 6.1; Packing Group: II
Crystalline; Linear Formula: Na2HAsO4·7H2O; MW: 312.01
Melting Point: 180°
Density (g/mL): 1.88
Catalog Number:
(76466-818)
Supplier:
Boster Biological Technology
Description:
Sandwich High Sensitivity ELISA kit for quantitative detection of mouse Serpin D1. 96 wells/kit, with removable strips.
Catalog Number:
(10474-136)
Supplier:
Bioss
Description:
This gene is a member of the brain expressed X-linked gene family. The proteins encoded by some of the other members of this family act as transcription elongation factors which allow RNA polymerase II to escape pausing during elongation. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2011].[SUBCELLULAR LOCATION] [PTM] [SIMILARITY]
Catalog Number:
(10361-234)
Supplier:
Bioss
Description:
Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.
Supplier:
BeanTown Chemical
Description:
CAS: 67-56-1; EC No: 200-659-6; MDL No: MFCD00004595; RTECS: PC1400000
UN No: UN1230; Haz Class: 3; Packing Group: II
Liquid; Linear Formula: CH3OH; MW: 32.04
Melting Point: -98°; Boiling Point: 64.7°; Flash point: 9.7°C (49.5°F)
Density (g/mL): 0.791; Refractive Index: 1.329
Catalog Number:
(10329-126)
Supplier:
Bioss
Description:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions. [provided by RefSeq].
Supplier:
BeanTown Chemical
Description:
CAS: 75-05-8; EC No: 200-835-2; MDL No: MFCD00001878; RTECS: AL7700000
UN No: UN1648; Haz Class: 3; Packing Group: II
Liquid; Linear Formula: CH3CN; MW: 41.05
Melting Point: -48°; Boiling Point: 81-82°; Flash point: 2°C (36°F)
Density (g/mL): 0.786; Refractive Index: 1.344
Catalog Number:
(10284-390)
Supplier:
Bioss
Description:
There are two forms of glutamic acid decarboxylases (GADs) that exist in brain: GAD-65 (also known as GAD2) and GAD-67 (also known as GAD1, GAD or SCP). GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA (gamma-aminobutyric acid) from L-glutamic acid. Although both GADs are found in brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 transiently activates to assist in GABA production. As a member of the group II decarboxylase family, GADL1 (Glutamate decarboxylase-like protein 1) is a 521 amino acid protein that utilizes pyridoxal phosphate as a cofactor for its carboxylase activity. There are two isoforms of GADL1 that exist as a result of alternative splicing events.
Supplier:
Brandtech
Description:
This stand for the HandyStep® touch pipette securely holds the device, even with a PD-Tip II inserted, and saves space on the laboratory bench. It can be used for both the HandyStep® touch and the HandyStep® touch S.
Catalog Number:
(10361-228)
Supplier:
Bioss
Description:
Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.
Supplier:
BeanTown Chemical
Description:
CAS: 136-53-8; EC No: 205-251-1; MDL No: MFCD00053316
UN No: UN1268; Haz Class: 3; Packing Group: III
Liquid; Linear Formula: [CH3(CH2)3CH(C2H5)CO2]2Zn; Molecular Formula: C16H30O4Zn ; MW: 351.79
Density (g/mL): 1.07
Catalog Number:
(10104-626)
Supplier:
Prosci
Description:
Brg- or hBrm-associated factor (BAF) complexes, a chromatin-remodeling complex family of mammalian cells, facilitate transcriptional activity by remodeling nucleosome structure. Brg1 is the core subunit of Brg-associated factor complexes. BAF complexes can interact with NF1/CTF and RNAP II, and this interaction is closely dependent on the activation of gene transcription.
Catalog Number:
(10305-728)
Supplier:
Bioss
Description:
Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3; integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing. The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro. Replication stress response protein; the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage. In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6. Promotes cardiac myocyte enlargement. RPB1/POLR2A phosphorylation on 'Ser-2' in CTD activates transcription. AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth.
Supplier:
BeanTown Chemical
Description:
CAS: 92112-69-1; EC No: 295-570-2; MDL No: MFCD02179311
UN No: UN1208; Haz Class: 3; Packing Group: II
Liquid; Molecular Formula: C6H14; MW: 86.18
Melting Point: -95°; Boiling Point: 68-70°; Flash point: -23°C (-9°F)
Density (g/mL): 0.672; Refractive Index: 1.379
Supplier:
BeanTown Chemical
Description:
CAS: 64-19-7; EC No: 200-580-7; MDL No: MFCD00036152
UN No: UN2789; Haz Class: 8 (3); Packing Group: II
Liquid; Linear Formula: CH3CO2H; MW: 60.05
Melting Point: 16.2°; Boiling Point: 117-118°; Flash point: 40°C (104°F)
Density (g/mL): 1.049; Refractive Index: 1.371
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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