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N\'-[2-(4-Chlorophenyl)-1-cyclopropylaminoethylidene]hydrazinecar
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N\'-[2-(4-Chlorophenyl)-1-cyclopropylaminoethylidene]hydrazinecar
Supplier:
ALADDIN SCIENTIFIC
Description:
3-Amino-5-methylthio-1H-1,2,4-triazole was used in the synthesis of heterocyclic disperse azo dyes based on 8-hydroxyquinoline.
Supplier:
TCI America
Description:
CAS Number: 34552-83-5
MDL Number: MFCD00058581
Molecular Formula: C29H33ClN2O2
Molecular Weight: 513.50
Purity/Analysis Method: <gt/>98.0% (T,HPLC)
Form: Crystal
Melting point (°C): 223
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 045563-1G , MDL Number: MFCD00140420
Supplier:
ALADDIN SCIENTIFIC
Description:
Shipped at 4°C. Store at -20°C. Store under desiccating conditions.Product descriptionNavitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM.
Supplier:
AMBEED, INC
Description:
ABT-199 99%, Ambeed.Inc
Supplier:
TCI America
Description:
CAS Number: 22459-81-0
MDL Number: MFCD00040848 Molecular Formula: C8H7BrClNO Molecular Weight: 248.50 Purity/Analysis Method: >98.0% (GC) Form: Crystal Melting point (°C): 125
Supplier:
TCI America
Description:
CAS Number: 3460-23-9
MDL Number: MFCD00040852 Molecular Formula: C8H7BrClNO Molecular Weight: 248.50 Purity/Analysis Method: >98.0% (GC) Form: Crystal Melting point (°C): 151
Supplier:
Adipogen
Description:
Selumetinib (AZD6244) is a second-generation, orally available, potent and selective ATP non-competitive inhibitor of MEK 1/2. In direct assays, AZD6244 selectively inhibits purified active MEK1 and MEK2 with an IC(50) of 14nM, and AZD6244 has reported IC(50) values of <lt/>100nm for MEK1 in ELISA assays and in bindings assays against recombinant domains of MEK2, Kd values were 53nM for AZD6244. AZD6244 demonstrated very effective anti-proliferation effects against several different cell lines with IC(50) values ranging from a low of 3nM to <lt/> 1µM depending upon the cell system used, and the compound inhibits basal and growth factor-stimulated phosphorylation of ERK1/ 2 with IC(50) concentrations <lt/> 40nM. AZD6244 has demonstrated potent dose-dependent antitumor activity against a panel of mouse xenograft models of colorectal, pancreatic, liver, skin, and lung cancer, and inhibition of tumor growth was found to correlate with the reduction of phospho-ERK1/2 levels in tumors.
Supplier:
AMBEED, INC
Description:
ABT-263 98%
Catalog Number:
(TCC0873-025G)
Supplier:
TCI America
Description:
CAS Number: 113-92-8
MDL Number: MFCD00069225 Molecular Formula: C16H19ClN2 Molecular Weight: 390.86 Purity/Analysis Method: >99.0% (HPLC,T) Form: Crystal Melting point (°C): 135
Supplier:
Adipogen
Description:
Aurora kinases constitute a family of serine-threonine kinases that are strongly associated with cancer. Aurora A and B are essential in mitosis. Perturbation of their activity leads to multiple defects in mitosis including aberrant centrosome duplication, misalignment of chromosomes, inhibition of cytokinesis, and disruption of the spindle checkpoint. The role of Aurora C is unclear; however, Aurora C can complement Aurora B kinase activity in mitosis. SNS-314 is an ATP-competitive, selective, and potent nanomolar inhibitor of aurora kinases in vitro. A cocrystal structure of SNS-314 with Aurora A confirms that SNS-314 engages the purine-binding pocket of Aurora. SNS-314 inhibits cellular proliferation in the HCT116 colorectal carcinoma cell line with an EC50 of ~5nM. Analysis of DNA content and indirect immunofluoresence demonstrates that SNS-314 induces defects in cytokinesis and spindle checkpoint that are consistent with Aurora kinase inhibition. Phosphorylation of Histone H3 on serine 10, a known Aurora B cellular target, is inhibited with an EC50 of ~9nM following treatment of cells with SNS-314. Administration of SNS-314 to HCT116 tumor bearing mice potently suppresses tumor growth. Analysis of SNS-314 treated tumors confirms that the anti-tumor activity is consistent with Aurora kinase inhibition. SNS-314 is a potent small-molecule inhibitor of Aurora kinase that is being developed as a novel anti-cancer therapeutic agent.
Supplier:
Enzo Life Sciences
Description:
Venetoclax is a Bcl-2-selective inhibitor with Ki of <0.01 nM, >4800-fold more selective versus Bcl-xL and Bcl-w, and no activity to Mcl-1
Supplier:
ALADDIN SCIENTIFIC
Description:
ABT-199 (GDC-0199) is a BH3 mimetic that Bcl-2-selective inhibitor with Ki of <0.01 nM. B-cell lymphoma/leukemia 2 (Bcl-2) is an anti-apoptotic protein that controls cell survival by binding the BH3 domains of pro-death BAD and BAK proteins and preventing permeabilization of the mitochondrial outer membrane. This protein is tightly regulated for the homeostasis between cell growth and cell death.A Bcl-2-selective inhibitor with Ki of <0.01 nM
Supplier:
Matrix Scientific
Description:
MF=C8H6BRFO2 MW=233.04 CAS=786652-63-9 MDL=MFCD09864663 5G
Catalog Number:
(102600-262)
Supplier:
Chem Impex International
Description:
2-(4-CHLOROPHENYL)-2-(4- 250MG
Catalog Number:
(102602-514)
Supplier:
Chem Impex International
Description:
(5-(4-CHLOROPHENYL)-3-IS 1G
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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