(2-Chloro-4-methylphenyl)cyclopropylmethanone
Supplier:
AMBEED, INC
Description:
4,6-Dichloro-1-(oxan-2-yl)-1H-pyrazolo[3,4-d]pyrimidine, Purity: 98%, CAS Number: 1037479-62-1, Appearance: Solid, Storage: Inert atmosphere, 2-8C, Size: 5G
Supplier:
Matrix Scientific
Description:
N,N-Dimethylvaline hydrochloride
Supplier:
APOLLO SCIENTIFIC
Description:
2,3-Dihydro-5-[(methylamino)methyl]thieno[3,4-b][1,4]dioxine 95%
Supplier:
ALADDIN SCIENTIFIC
Description:
Isonicotinamidine hydrochloride ≥98%
Supplier:
AOB CHEM USA
Description:
2-(3,4-Dichloro-2-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane ≥97%
Supplier:
AMBEED, INC
Description:
1H-Pyrazolo[3,4-d]pyrimidine, Purity: 97%, CAS Number: 271-80-7, Appearance: Pale-yellow to Yellow-brown Solid, Storage: Inert atmosphere, Room Temperature, Size: 250mg
Supplier:
APOLLO SCIENTIFIC
Description:
Azetidin-3-ol hydrochloride 97%
Supplier:
AOB CHEM USA
Description:
1-Bromo-3,4-Difluoro-2-Methoxy-5-(Methylsulfonyl)Benzene ≥97%
Supplier:
AMBEED, INC
Description:
2-Ethylphenylhydrazine hydrochloride 98+%
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 044104-5G , MDL Number: MFCD00202283
Supplier:
Matrix Scientific
Description:
3-Chloroazetidine Hydrochloride, MF=C3H7Cl2N MW=128.00 CAS: 313468-63-2 25G
Supplier:
Matrix Scientific
Description:
4-Methylthiopiperidine Hydrochloride, MF=C6H14Clns MW=167.70 CAS: 208245-70-9 500Mg
Catalog Number:
(101812-534)
Supplier:
Matrix Scientific
Description:
3-(3-Methoxyphenyl)piperidine hydrochloride
Supplier:
AMBEED, INC
Description:
3,4-Bis(2-methoxyethoxy)benzonitrile, Purity: 97%, CAS number: 80407-68-7, Appearance: Solid, Storage: Sealed in dry, Room Temperature, Size: 5G
Supplier:
AMBEED, INC
Description:
tert-Butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate, Purity: 98%, CAS Number: 164148-92-9, Appearance: White to yellow-brown or pale-red solid, Storage: Keep in dark place, Sealed in dry, 2-8C, Size: 10G
Catalog Number:
(101189-698)
Supplier:
BioVendor
Description:
Cyclophilins belong to a group of proteins that have peptidyl-prolyl cis-trans isomerase activity; such proteins are collectively known as immunophilins and also include the FK-506-binding proteins and the parvulins. Cyclophilins are found in all cells of all organisms studied, in both prokaryotes and eukaryotes. Human have a total of 16 cyclophilin proteins. Cyclophilins also have varying degrees of affinity for the immunosuppressive drug Cyclosporine A (CsA), a cyclic 11-amino-acid peptide produced by fungus Tolypocladium infantum. Cyclophilin A, in particular, is the major intracellular receptor for CsA. Cyclophilin A (CYPA) is the first member of the cyclophilins to be identified in mammals. Human genes of CYPA, also known as Cyp18, are located on chromosome 7p11.2-p13 and encode the protein, which consists of 165 amino acid residues with a relative molecular mass approximately 18 kDa. Human CYPA has an eight-stranded antiparallel β-barrel structure, with two α-helices enclosing the barrel from either side. Seven aromatic and other hydrophobic residues form a compact hydrophobic core within the barrel, usually in the area where CsA binds. A loop from Lys118 ti His126 and four β-strands (β3-β6) make up the binding site for CsA. In mammals, the CsA-CYPA complex binds to and inhibits calcineurin, a calcium-calmodulin-activated serine/threonine-specific protein phosphatase. The inhibition of calcineurin blocks the translocation of nuclear factor of activated T cells from the cytosol to the nucleus, thus preventing the transcription of genes encoding cytokines such as interleukin-2.
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