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Pyrido[2,3-d]pyrimidin-4(1H)-one
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Pyrido[2,3-d]pyrimidin-4(1H)-one
Supplier:
AMBEED, INC
Description:
5-Bromo-2-(piperazin-1yl)pyrimidine 98%
Catalog Number:
(89350-852)
Supplier:
Genetex
Description:
Tau proteins are microtubule-associated proteins that are abundant in neurons in the central nervous system and are less common elsewhere. They were discovered in 1975 in Marc Kirschner's laboratory at Princeton University. Tau proteins interact with tubulin to stabilize microtubules and promote tubulin assembly into microtubules. Tau has two ways of controlling microtubule stability: isoforms and phosphorylation. Six tau isoforms exist in brain tissue, and they are distinguished by their number of binding domains. Three isoforms have three binding domains and the other three have four binding domains. The binding domains are located in the carboxy-terminus of the protein and are positively-charged (allowing it to bind to the negatively-charged microtubule). The isoforms with four binding domains are better at stabilizing microtubules than those with three binding domains. The isoforms are a result of alternative splicing in exons 2,3, and 10 of the tau gene. Phosphorylation of tau is regulated by a host of kinases. For example, PKN, a serine/threonine kinase. When PKN is activated, it phosphorylates tau, resulting in disruption of microtubule organization. Hyperphosphorylation of the tau protein (tau inclusions), however, can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease and other tauopathies. Tau protein is a highly soluble microtubule-associated protein (MAP). In humans, these proteins are mostly found in neurons compared to non-neuronal cells. One of tau's main functions is to modulate the stability of axonal microtubules. Tau is not present in dendrites and is active primarily in the distal portions of axons where it provides microtubule stabilization but also flexibility as needed. This contrasts with STOP proteins in the proximal portions of axons which essentially lock down the microtubules and MAP2 that stabilizes microtubules in dendrites. The tau gene locates on chromosome 17q21, containing 16 exons. The major tau protein in the human brain is encoded by 11 exons. Exon 2, 3 and 10 are alternative spliced, allowing six combinations (2-3-10-; 2+3-10-; 2+3+10-; 2-3-10+; 2+3-10+; 2+3+10+). Thus, in the human brain, the tau proteins constitute a family of six isoforms with the range from 352-441 amino acids. They differ in either no, one or two inserts of 29 amino acids at the N-terminal part (exon 2 and 3), and three or four repeat-regions at the C-terminal part exon 10 missing. So, the longest isoform in the CNS has four repeats (R1, R2, R3 and R4) and two inserts (441 amino acids total), while the shortest isoform has three repeats (R1, R3 and R4) and no insert (352 amino acids total). All of the six tau isoforms are present in an often hyperphosphorylated state in paired helical filaments from Alzheimer's Disease brain. In other neurodegenerative diseases, the deposition of aggregates enriched in certain tau isoforms has been reported. When misfolded this otherwise very soluble protein can form extremely insoluble aggregates that contribute to a number of neurodegenerative diseases.
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 041220-1G , MDL Number: MFCD06795939
Supplier:
Matrix Scientific
Description:
4-(2-Thienyl)pyrimidine-2-thiol ≥97%
Catalog Number:
(102894-742)
Supplier:
AMBEED, INC
Description:
1-Pyrimidin-2-ylethanone 97%
Catalog Number:
(77404-844)
Supplier:
APOLLO SCIENTIFIC
Description:
3-Bromoimidazo[1,2-a]pyrimidine 98%
Supplier:
APOLLO SCIENTIFIC
Description:
2-Chloro-5-(trifluoromethyl)pyrimidine 97%
Supplier:
AMBEED, INC
Description:
5-Bromo-2-(bromomethyl)pyrimidine 97%
Catalog Number:
(TCD2589-005G)
Supplier:
TCI America
Description:
CAS Number: 40497-30-1
MDL Number: MFCD00006104 Molecular Formula: C5H6N2O2 Molecular Weight: 126.12 Purity/Analysis Method: >96.0% (T) Form: Crystal
Supplier:
AMBEED, INC
Description:
2-(Trifluoromethyl)pyrimidine, Purity: 97%, CAS Number: 116470-67-8, Appearance: Liquid, Storage: Sealed in dry, Room Temperature, Size: 100mg
Supplier:
Matrix Scientific
Description:
MF=C10H9N3 MW=171.20 Cas=57356-49-7 MDL=MFCD01646270 25G
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 045336-500MG , MDL Number: MFCD01443687
Supplier:
Matrix Scientific
Description:
Indole ≥97%
Supplier:
APOLLO SCIENTIFIC
Description:
2-(Tributylstannyl)pyrimidine
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
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