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cis-\u200BEthyl+4-\u200Baminocyclohexanecarb\u200Boxylate+HCl+sal
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cis-\u200BEthyl+4-\u200Baminocyclohexanecarb\u200Boxylate+HCl+sal
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Catalog Number:
(EM1.12292.0005)
Supplier:
MilliporeSigma
Catalog Number:
(75929-258)
Supplier:
Rockland Immunochemical
Description:
IRS1 is the substrate for the insulin tyrosine kinase receptor and is found in a variety of insulin-responsive cells and tissues. IRS1 protein has no intrinsic enzymatic activity but acts as a docking protein, via the SH2 domains, for mediating the insulin downstream signaling events. IRS1 has been shown to associate with the 14-3-3 family of proteins and this could play a role in the regulation of insulin sensitivity by interrupting the association between the insulin receptor and IRS1 (1). IRS1 may be associated with colorectal cancer and diet and related factors may affect the risk by modifying plasma insulin levels. Thus, the inter-individual variation in insulin signaling mediated by IRS1 may play a plausible role in the development of colorectal cancer (2). IRS1 Protein is ideal for investigators involved in Signaling Reagents, Protein Substrates, AKT/PKB Pathway, Cancer, Cellular Stress, and ERK/MAPK Pathway research.
Catalog Number:
(TCP0599-100G)
Supplier:
TCI America
Description:
CAS Number: 569-61-9
MDL Number: MFCD00001657
Molecular Formula: C19H17N3
Molecular Weight: 323.82
Purity/Analysis Method: <gt/>95.0% (HPLC)
Form: Crystal
Melting point (°C): 270
Lambda max.: 539 nm (EtOH)
Supplier:
Thermo Scientific Chemicals
Description:
In pigments, galvanic batteries, lithography, weighting fabrics
Supplier:
MP Biomedicals
Description:
Chlorpromazine Hydrochloride is a phenothiazine antipsychotic; a D2 and H1 antagonist. It inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase and nitric oxide synthase and is reported to uncouple and inhibit oxidative phosphorylation at 10-3 - 10-4 M. It is possibly a photogenotoxic agent in humans. Helps to induce hypothermia in mice in the dose range of 12.5 -100 mg/kg.
Chlorpromazine demonstrates cytotoxic and antiproliferative activity against leukemic cells, but does not affect the viability of normal lymphocytes. Phenothiazine antipsychotic; D2 dopamine receptor antagonist, H1 histamine receptor antagonist; inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase and nitric oxide synthase.
Catalog Number:
(75932-918)
Supplier:
Rockland Immunochemical
Description:
TINP1 (TGF-beta inducible nuclear protein 1), also known as NSA2 (Nop seven-associated 2), is a highly conserved nucleolar protein essential for large ribosomal subunit biogenesis. NSA2 is broadly expressed in human tissues and cultured cell lines, and located in the nucleolus of the cell. It is thought to be involved in cell proliferation and cell cycle regulation.
Supplier:
MP Biomedicals
Description:
Nisin is a polypeptide (34 residues) antibiotic structurally similar to subtilin but containing no tryptophan; a member of the lantibiotic family. Reduces the thermal resistance of bacterial spores in milk-based beverages.The C-terminus of nisin is responsible for the initial interaction of nisin, binding to the target membrane. Active against Gram-positive bacteria at the cytoplasmic membrane.
Supplier:
Thermo Scientific Chemicals
Description:
1g CAS: 32529-79-6, MDL: MFCD06797561
Supplier:
Adipogen
Description:
Natural fluorescent dye, used in histology for staining heparin in mast cells. An isoquinoline alkaloid, which shows antibacterial, antifungal, anti-inflammatory, anti-oxidant, antidiabetic, antiviral and anticancer activity. It inhibits cell growth and induces apoptosis in a variety of cancer cell lines. Broad spectrum enzyme inhibitor, affects N-acetyltransferase, cyclooxygenase-2, and topoisomerase activities and gene/protein expression. Increases adiponectin expression, upregulates LDLR and insulin receptor. Anti-hyperglycemic, by inhibition of aldose reductase, inducing glycolysis, preventing insulin resistance through increasing insulin receptor expression and acting like incretins. Activates AMPK and ERK. Potent, uncompetitive, reversible IDO 1 inhibitor with IC50 values of 7 µM (cell-based assay) and 9.3 µM (enzymatic assay), and Ki value 8µM.
Catalog Number:
(75794-152)
Supplier:
Prosci
Description:
PARP-1 (ARTD1) is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. PARP-1 positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. It forms a complex with EEF1A1 and TXK that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. PARP-1 (E998K mutant) is an inactive form of PARP-1 which can be used as a control compound.
Supplier:
Adipogen
Description:
Fluorescent dye. Fluorophore standard that is widely used in enzyme assay systems. Precursor for a variety of R110-based enzyme substrates for flow cytometric measurements. Used as a calibration standard for R110-based enzyme substrates. Compared to AMC and AFC enzyme substrates, fluorogenic R110 substrates are generally more sensitive, giving longer absorption and fluorescence wavelength than AMC and AFC substrates. Spectral data: lambdaex 498nm| lambdaem 520nm in methanol.
Catalog Number:
(75929-906)
Supplier:
Rockland Immunochemical
Description:
MDM2 is a nuclear phosphoprotein that binds and inhibits transactivation by p53, as part of an autoregulatory negative feedback loop (1). Overexpression of the MDM2 gene product can lead to excessive inactivation of p53 thereby diminishing its tumor suppressor function. The inactivation of p53 is mediated by the E3 ubiquitin ligase activity of MDM2 which targets p53 for proteasomal degradation. MDM2 also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5 (2). Amplification of MDM2 is frequently observed in human sarcomas and this is consistent with the hypothesis that MDM2 binds to p53 which then leads to escape from p53-regulated growth control. MDM2 Protein is ideal for investigators involved in Sigaling Proteins, Cell Cycle Proteins, AKT/PKB Pathway, Apoptosis/Autophagy, Cancer, Cell Cycle, and Cellular Stress research.
Supplier:
MP Biomedicals
Description:
A modified tripeptide reversible protease inhibitor of trypsin-like proteases and some cysteine proteases including endoproteinase Lys-C, kallikrein, papain, thrombin, cathepsin B, cathepsins H and L, trypsin, calpain, trypsin and plasmin. Little to no inhibition is seen against pepsin, cathepsins A and D and alpha-chymotrypsin. When adjusted for molarity, all three salt forms are equally effective; however, the hydrochloride salt is usually less invasive in biological settings. Leupeptin, because of its aldehyde group, may act as a reducing agent and therefore interfere in protein determinations such as Lowry and, to a lesser extent, Bradford.
Catalog Number:
(RC27051)
Supplier:
Ricca Chemical
Description:
Disodium ethylenediaminetetraacetate dihydrate. CAS RN 6381-92-6. Formula Weight: 372.30. Solution, 0.05 M. Packaged in a plastic container. 1 gal.
Supplier:
Thermo Scientific Chemicals
Description:
Stripping tin coating from steel surfaces, in organic synthesis, as catalyst, in making other antimony salts, in chemical microscopy for drug identification
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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