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Van Der Voort Lucht en Milieu Amste
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Van Der Voort Lucht en Milieu Amste
Catalog Number:
(102512-712)
Supplier:
Adipogen
Description:
BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. BAFF co-stimulates activated T cells. Increased levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases, such as Sjögren’s syndrome, rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus (SLE). Furthermore, BAFF is found in inflammatory sites in which there is lymphoid neogenesis. BAFF levels are elevated in patients with multiple myeloma and B cell chronic lymphoid leukemia (B-CCL).
Supplier:
Adipogen
Description:
BMS387032 is a novel cyclin-dependent kinase inhibitor, which exhibits potent and selective inhibitory activity against Cdk2, Cdk7, and Cdk9. It inhibits CDK2 with an IC(50) of 48nM and up to 20-fold selective over CDK1/CDK4. It also inhibits CDK7/9 with IC(50) values of 62nM and 4nM. It has little effect on CDK6.
Supplier:
Adipogen
Description:
Potent and selective endothelin B receptor (ETBR) antagonist.
Supplier:
Adipogen
Description:
LIGHT (HVEML; CD258) is a cytokine that binds to TNFRSF3/LTBR. It activates NF-kappaB, stimulates the proliferation of T cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
Catalog Number:
(102512-562)
Supplier:
Adipogen
Description:
Human CD70 is not present on resting lymphocytes. CD70 is expressed after activation on about 20% of T cells and on about 70% of B cells. CD70 is a ligand for CD27 and it is also a member of the TNF gene family.
Supplier:
Adipogen
Description:
Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1(MAPK3)/ERK2(MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
Catalog Number:
(102512-666)
Supplier:
Adipogen
Description:
Streptavidin can be used in conjunction with biotinylated antibodies as an avidin/biotin labeling system for flow cytometry.
Catalog Number:
(102514-686)
Supplier:
Adipogen
Description:
Insulin-growth factor-like gene family is a new family of proteins consisting of four proteins in humans (IGFL1 to 4) and one in mice (mIGFL). mIGFL is expressed in normal skin in mice and further upregulated during inflammation responses in skin or after skin wounding. In human only IGFL1 expression is increased in psoriatic skin samples. Mouse IGFL and human IGFL1 and 3 interact with specificity and high affinity to a novel receptor named IGF-like family receptor 1 (formerly TMEM-149). Analysis of the amino acid sequence of IGFLR1 indicated that this receptor is likely a novel member of the TNFR family. IGFLR1 is expressed most abundantly on mouse T cells, suggesting that mIGFL and IGFL1 produced in the skin may potentially exert regulatory functions on T cell responses.
Supplier:
Adipogen
Description:
PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with an IC(50) of 9.1nM for the PI3K family when tested AKT phosphorylation in BT20 cells. In direct kinase assays, PF-04979064 has potent Ki values against PI3Kalpha (Ki= 0.13nM human, 0.299nM mouse) and PI3Kgamma (Ki=0.111nM), and PI3Kdelta (Ki=0.122nM). In contrast, Ki values for non-PI3K kinases such as mTOR were 10X higher at 1.42 nM.
Catalog Number:
(102512-846)
Supplier:
Adipogen
Description:
CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.
Supplier:
Adipogen
Description:
NVP-BGT226 is a novel, orally bioavailable small-molecule inhibitor of phosphoinositol-3-kinase and mammalian target of rapamycin with an IC(50) of 1nM.
Supplier:
Adipogen
Description:
Specific cell permeable SIRT1 (sirtuin 1) inhibitor. Senescence-like growth arrest inducer. Platelet aggregation inhibitor. Apoptosis inducer.
Supplier:
Adipogen
Description:
AMG-25 exhibits potent inhibition of c-Kit with greater than 200-fold selectivity over KDR, p38, Lck and Src.
Catalog Number:
(102979-340)
Supplier:
Adipogen
Description:
Human CD155 (Polio Virus Receptor, PVR, Necl-5) is a 70kd type I Ig superfamily molecule. It is involved in formation of intracellular junctions between epithelial cells. Its ligands include CD226 (DNAM-1), and CD96 (TACTILE). CD155 expression by tumor has been shown to be upregulated by nitric oxide. A soluble version of CD155 has been shown to exist. High CD155 expression has recently been exploited to use engineered poliovirus to treat glioblastoma.
Supplier:
Adipogen
Description:
Cell permeable Sonic hedgehog (Shh) agonist. Cell permeable smoothened (Smo) agonist. Induces Sonic hedgehog (Shh) pathway activation and counteracts cyclopamine inhibition of Smo. Acts as an activator of Smo at low concentrations and as an inhibitor of Smo at very high concentrations. Potent activator of VEGF expression in vitro.
Supplier:
Adipogen
Description:
Used in fluorimetric studies. Fluorescent probe. Selective fluorometric substrate for CYP2C19 and CYP1A1. Reaction product of the substrate 3-O-methylfluorescein phosphate (OMFP) is hydrolyzed by phosphatases to yield O-methylfluorescein (OMF) that is detected at a 485nm excitation/525nm emission.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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