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Van Der Voort Lucht en Milieu Amste
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Van Der Voort Lucht en Milieu Amste
Catalog Number:
(102512-082)
Supplier:
Adipogen
Description:
Antibodies to human CD17 react with lactosylceramide which is expressed on granulocytes, monocytes, platelets and basophils. CD17 expression is downmodulated on activated granulocytes. CD17 is an important component in CD11b/CD18 mediated phagocytosis of microbes.
Supplier:
Adipogen
Description:
New class of highly photostable, water soluble fluorescent labels with large Stoke′s shift, high QY in aqueous media and pH tolerance.
Supplier:
Adipogen
Description:
Non-selective COX inhibitor. The IC50 values for human recombinant COX-1 and -2 are 0.6-4.8 µM and 2.0-28.4 µM, respectively. Naproxen is a potent, non-steroidal, non-selective anti-inflammatory compound that acts as a Cox (cyclooxygenase) inhibitor, and inhibits both Cox-1 and Cox-2. Research indicates that the S-naproxen is a more active form than the R-naproxen. The S-naproxen enantiomer was observed to inhibit platelet aggregation, and both enantiomers decrease production of thromboxane B2. Naproxen has been demonstrated to block Abeta fibril growth and form a complex with copper (II).
Supplier:
Adipogen
Description:
6-TAMRA N-succinimidyl ester is an amine-reactive form of 6-carboxytetramethylrhodamine.
Catalog Number:
(102512-320)
Supplier:
Adipogen
Description:
Human CD41 is a member of a major platelet transmembrane glycoprotein complex (CD41/CD61) which mediates platelet aggregation and adhesion by serving as the receptor for fibrinogen and von Willebrand factor, fibronectin and vitronectin.
Catalog Number:
(102513-116)
Supplier:
Adipogen
Description:
Human CD272 (BTLA; B and T Lymphocyte Attenuator) is a member of the immunoglobulin superfamily and has sequence homology to PD-1 and CTLA-4. It is expressed on T and B lymphocytes and other hemopoetic lineages. Engagement of this molecule by its ligand CD270 (HVEM) can downregulate activated T and B cell responses. CD272 levels on antigen specific CD8+ T cells have been reported to decrease in viral specific, but not melanoma specific activated lines. Polymorphism of the CD272 molecule has been linked to rheumatoid arthritis.
Catalog Number:
(102514-566)
Supplier:
Adipogen
Description:
The Notch ligand delta-like protein 1 (DLL1) is essential for postnatal arteriogenesis and contributes to tumor progression. DLL1 is involved in differentiation and self-renewal of adipocyte stem cells. Blocks the differentiation of progenitor cells into the B cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor.
Supplier:
Adipogen
Description:
Immunosuppressant. Calcineurin inhibitor with lower activity than Cyclosporin A (AG-CN2-0079). Antifungal. Antitumor.
Catalog Number:
(102514-788)
Supplier:
Adipogen
Description:
IDO catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway. Proinflammatory mediators, such as endotoxin and IFN-gamma induce the expression of IDO in several tissues. IDO-dependent suppression of T cell responses might function as natural immunoregulatory mechanism. Physiological IDO activity has been implicated in T cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders.
Catalog Number:
(102513-674)
Supplier:
Adipogen
Description:
Asperlactone is an antibiotic.
Catalog Number:
(102511-746)
Supplier:
Adipogen
Description:
Human T cell receptor (TCR) is a T cell surface expressed heterodimer of alpha/beta or gamma/delta chains. TCR’s recognize antigen peptides bound to MHC molecules forming the basis of antigen specific response by T cells.
Supplier:
Adipogen
Description:
Potent and highly selective, irreversible inhibitor of soluble guanylyl cyclase (sGC). The binding is competitive with nitric oxide (NO). Tool to elucidate the nitric oxide (NO)-cGMP pathway. Apoptosis inhibitor Inhibits growth and migration of prostate cancer cells independent of its effects on GMP levels.
Catalog Number:
(102513-900)
Supplier:
Adipogen
Description:
Interleukin-35 (IL-35) is a novel IL-12 family cytokine produced by regulatory T cells (Treg) but not by resting or activated effector T cells (Teff). IL-35 is a heterodimeric protein composed of EBI3 (Epstein-Barr-Virus-induced gene 3) and IL-12a (p35). EBI3 is a downstream target of Foxp3, a transcription factor required for Treg-cell development and function, and thus Treg-cell restriction of IL35 occurs. Regulatory T cells are essential for maintaining self tolerance and preventing autoimmunity, and IL-35 is identified as a molecule that mediates the immune suppression function of Treg-cell. As an inhibitory cytokine, IL-35 induces proliferation of Treg-cell populations but suppresses Th17 cell development. Studies in mice show the absence of either IL-35 chain from Treg-cell reduces the cells' ability to suppress inflammation using an experimental model for inflammatory bowel disease. IL-35 is suggested as a potential target of immunotherapy. Recently, insufficient IL-35 levels were shown to play a pivotal role in the development of type 1 diabetes (T1D) and autoimmune diseases.
Catalog Number:
(102512-512)
Supplier:
Adipogen
Description:
Human CD63 is expressed on activated platelets and also on monocytes and macrophages. CD63 contains four hydrophobic transmembrane regions and is a member of the tetraspan family. CD63 appears to be involved with cell adhesion and associates with VLA-3 and VLA-6 integrins. In a colon cancer model, it has been correlated to metastatic potential.
Supplier:
Adipogen
Description:
Dealkylase substrate for the microfluorimetric analysis of microsomal cytochrome P-450.
Catalog Number:
(102512-782)
Supplier:
Adipogen
Description:
Immunoglobulin expressed by the mouse plasmacytoma MOPC 31C is an IgG1kappa isotype of unknown specificity. It is used as a negative control when working with human cells.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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