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Van Der Voort Lucht en Milieu Amste
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Van Der Voort Lucht en Milieu Amste
Catalog Number:
(102981-772)
Supplier:
Adipogen
Description:
Human CD155 (Polio Virus Receptor, PVR, Necl-5) is a 70kd type I Ig superfamily molecule. It is involved in formation of intracellular junctions between epithelial cells. Its ligands include CD226 (DNAM-1), and CD96 (TACTILE). CD155 expression by tumor has been shown to be upregulated by nitric oxide. A soluble version of CD155 has been shown to exist. High CD155 expression has recently been exploited to use engineered poliovirus to treat glioblastoma.
Catalog Number:
(102513-324)
Supplier:
Adipogen
Description:
Human DR3 (TRAMP; LARD) was designated TNF receptor superfamily member 25. TL1A is a ligand which can induce apoptosis through a cytoplasmic death domain similar to the CD178-CD95 (FasL-Fas) interaction. Alternatively, engagement of DR3 on T cells can synergize with other activating signals to enhance IFNgamma production.
Catalog Number:
(102511-382)
Supplier:
Adipogen
Description:
Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
Catalog Number:
(102514-600)
Supplier:
Adipogen
Description:
CTRP5 (C1qTNF-related protein 5; C1QTNF5) belongs to a highly conserved family of adiponectin paralogs. CTRP5 mediates activation of AMP-activated protein kinase (AMPK) in muscle and liver cells, thereby regulating glucose and lipid metabolism. Serum levels of CTRP5 are significantly higher in obese/diabetic animal models compared to normal controls. Furthermore, CTRP5 may be a putative biomarker for mitochondrial dysfunction. Defects in C1QTNF5 are a cause of late-onset retinal degeneration (LORD).
Catalog Number:
(102512-832)
Supplier:
Adipogen
Description:
Immunoglobulin expressed by the mouse plasmacytoma TEPC 183 is an IgMkappa isotype of unknown binding specificity. It is used as a negative control when working with human cells.
Supplier:
Adipogen
Description:
N-Dodecanoyl-DL-homoserine lactone (C12-HSL) is a small diffusible signalling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism in bacteria. In addition to regulating bacterial functions, C12-HSL activates NF-kappaB in RAW 264.7 macrophages, increasing the expression of TNF-alpha, interleukin-1beta (IL-1beta) and IL-8, while other lactones do not. In addition, C12-HSL alters cell cycling and metabolism of human keratinocyte (HaCaT) cells. It also was shown to induce cell death by apoptosis.
Catalog Number:
(102511-786)
Supplier:
Adipogen
Description:
Human immunoglobulins are glycoproteins composed of two disulfide-bonded heavy (H) chain subunits, each of which is linked by interchain disulfide bonds to a light (L) chain forming a tetramolecular complex. There are five classes of immunoglobulins, designated IgG, IgA, IgM, IgD and IgE, which are defined by differences in the constant region of H chains. L chains are divided into kappa or lambda classifications based on structural antigenic differences. All classes of immunoglobulins have been found on the cell surface of B lymphocytes where they function as antigen receptors to elicit antigen-dependent proliferation and secretion of antigen specific soluble circulating antibodies.
Catalog Number:
(102512-890)
Supplier:
Adipogen
Description:
Human CD84 is a cell surface glycoprotein found on mature B lymphocytes, monocytes and a subset of T lymphocytes.
Catalog Number:
(102511-378)
Supplier:
Adipogen
Description:
Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
Catalog Number:
(102513-086)
Supplier:
Adipogen
Description:
Human CD137 (4-1BB) is expressed on activated T cells within 24-48 hours of activation. CD137 is a type I membrane protein and a member of the TNF receptor superfamily. CD137 appears to be important for T cell proliferation and survival and induces monocyte activation.
Catalog Number:
(102512-336)
Supplier:
Adipogen
Description:
Human CD43 is a heavily O-glycosylated and sialylated transmembrane protein that is mainly found on T cells, but not on B cells.
Catalog Number:
(102513-312)
Supplier:
Adipogen
Description:
BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. BAFF co-stimulates activated T cells. Increased levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases, such as Sjögren’s syndrome, rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus (SLE). Furthermore, BAFF is found in inflammatory sites in which there is lymphoid neogenesis. BAFF levels are elevated in patients with multiple myeloma and B cell chronic lymphoid leukemia (B-CCL).
Catalog Number:
(102514-482)
Supplier:
Adipogen
Description:
FABP3 is a fatty acid binding protein in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs regulate the fatty acid uptake, transport, and metabolism. FABP3 is expressed in a wide variety of tissues with highest concentration in cardiac and skeletal muscle. FABP3 was shown to be release from injured myocaridium and is an early and sensitive marker for injured myocardium.
Catalog Number:
(102512-942)
Supplier:
Adipogen
Description:
Human CD98 (4F2) is a heterodimeric glycoproein expressed on monocytes and activated cells. All cultured human cell lines tested express CD98. CD98 heavy chain mediates adhesion induced activation through integrin signaling.
Catalog Number:
(102512-938)
Supplier:
Adipogen
Description:
Human CD98 (4F2) is a heterodimeric glycoproein expressed on monocytes and activated cells. All cultured human cell lines tested express CD98. CD98 heavy chain mediates adhesion induced activation through integrin signaling.
Catalog Number:
(102514-656)
Supplier:
Adipogen
Description:
Asc promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. It is a component of the inflammasome, a protein complex which also includes NLRP3/NALP3, CARD8 and CASP1 and whose function is the activation of proinflammatory caspases.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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