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Catalog Number: (103259-678)

Supplier: Southern Biotechnology

Description: Purified Anti-Human IL-13 antibody for use in ELISA assays.

Catalog Number: (100245-230)

Supplier: Southern Biotechnology

Description: Swine Anti-Goat IgG(H+L)-FITC antibody with minimal reactivity to human, mouse, and rat serum proteins for use in flow cytometry, immunohistochemistry, and western blotting assays.

Catalog Number: (101442-914)

Supplier: Southern Biotechnology

Description: CD44, also known as phagocytic glycoprotein-1 (Pgp-1), exists as a large number of different isoforms resulting from alternative RNA splicing. The major isoform expressed on lymphocytes, myeloid cells, and erythrocytes is a glycosylated type I transmembrane protein. Other variable isoforms containing glycosaminoglycans have molecular weights ranging from 110 to 250 kDa and are widely expressed on hematopoietic and non-hematopoietic cells. CD44 contributes to the adhesion of leukocytes to endothelial cells, stromal cells, and the extracellular matrix. It also plays a functional role in cell migration, lymphocyte homing, and adhesion during hematopoiesis and lymphocyte activation.

Catalog Number: (100242-968)

Supplier: Southern Biotechnology

Description: Biotin Anti-Type II Collagen antibody for use in ELISA, immunohistochemistry / immunocytochemistry, electron microscopy, western blotting, and immunoprecipitation assays.

Catalog Number: (103264-642)

Supplier: Southern Biotechnology

Description: The CD117 (c-Kit) antigen is the cell-surface receptor for stem cell factor (SCF). Together these molecules constitute a ligand/receptor pair which functions to maintain normal hematopoiesis in the adult. Signaling through SCF/c-Kit has an important role in stimulating myeloid and erythroid production of primitive hematopoietic progenitor cells. A variety of cytokines act synergistically with SCF to stimulate proliferation and differentiation of bone marrow progenitor cells. For example, SCF plus IL-7 can stimulate the combined myeloid and B cell differentiation of uncommitted hematopoietic progenitor cells. SCF/c-Kit also participates in erythropoiesis in both the bone marrow and spleen. Loss-of-function mutations for SCF/c-Kit lead to a variety of pleiotropic developmental defects while gain-of-function mutations can lead to constitutive activation of the kit receptor and links to cancer. Examples of the former are mast cell deficiency and severe macrocytic anemia while the latter mutation has been identified in mastocytomas.

Catalog Number: (100243-886)

Supplier: Southern Biotechnology

Description: The monoclonal antibody 2F1 reacts with mouse killer cell lectin-like receptor G1 (KLRG1; formerly known as mouse MAFA), a homodimeric member of the lectin-like type 2 transmembrane receptor family that contain characteristic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their cytoplasmic domains. These ITIMs interact with the SH2 domains of protein phosphatases such as SHP-1. The 2F1 antibody stains 30-60% of NK1.1+CD3- splenocytes, and a small fraction of T cells in all mouse strains tested (C57BL/6, BALB/c, 129/J, C3H.SW, AKR/J, SJL). Cell surface expression of KLRG1 is up-regulated by expression of MHC class I molecules. The effect of MHC class I expression is indirect, and can be mediated by interactions with class I-specific Ly49 inhibitory receptors.

Catalog Number: (103265-416)

Supplier: Southern Biotechnology

Description: CD105, also known as endoglin, is a 90 kDa type II transmembrane glycoprotein that is expressed on the cell surface as a disulfide-linked homodimer and is found on endothelial cells. CD105 is one of several receptors for the various isoforms of TGF which in turn is one of a family of proteins involved in regulation of cell differentiation, migration of cells, and control on the immune response.

Catalog Number: (103265-716)

Supplier: Southern Biotechnology

Description: CD20 is a 33-37 kDa unglycosylated phosphoprotein. Although not a member of the tetraspanin superfamily of cell surface receptors, it crosses the cell membrane four times. It is expressed on all stages of B cell differentiation except plasma cells. The CD20 molecule is involved in regulation of B cell differentiation presumably via its reported function as a Ca++ channel subunit.

Catalog Number: (100245-242)

Supplier: Southern Biotechnology

Description: Sheep Anti-FITC-AP for use in ELISA and immunohistochemistry assays.

Catalog Number: (100244-072)

Supplier: Southern Biotechnology

Description: The IL-2 receptor is a complex of three distinct polypeptide chains: (i) the α chain which binds IL-2 with low affinity; (ii) the β chain that binds IL-2 with high affinity; and (iii) the common γ chain (γc) that does not bind IL-2. The high affinity receptor complex is an α/β/γ heterotrimer with a Kd of 1.3 x 10-11 M. In mouse spleen, CD122 is expresed on ~30% of CD8+ cells and all NK cells but <1% of B cells and CD4+ T lymphocytes. In the thymus, its expression is confined to CD4-CD8+ single positive and CD4-CD8- double negative cells. Cytoplasmic regions of the IL-2R β chain are involved in IL-2-mediated cellular signaling and, via the interaction of IL-2 and its receptor complex, may be involved in the generation and differentiation of T lymphocytes. The monoclonal antibody 5H4 does not block IL-2 binding.

Catalog Number: (101442-970)

Supplier: Southern Biotechnology

Description: CD42b, also known as GPIbα, is a two-chain membrane glycoprotein that forms a noncovalent complex with CD42a (GPIX) on the surface of platelets and megakaryocytes. Binding of the GPIb/GPIX heterodimer to von Willebrand factor bound to exposed subendothelial surfaces is essential for platelet adhesion at sites of injury.

Catalog Number: (103260-120)

Supplier: Southern Biotechnology

Description: Anti-Biotin may be used for indirect immunostaining when working with a biotinylated primary antibody. As an effective alternative to avidin, Anti-Biotin amplifies signal and reduces background that can be caused by avidin and its derivatives.

Catalog Number: (103264-374)

Supplier: Southern Biotechnology

Description: Goat Anti-Mouse IgG-Alexa Fluor 488 antibody with minimal reactivity to human proteins for use in flow cytometry, immunohistochemistry / immunocytochemistry, and western blotting assays.

Catalog Number: (100245-530)

Supplier: Southern Biotechnology

Description: Biotin Anti-Chicken IgA antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, ELISA, and immunoprecipitation assays.

Catalog Number: (101442-560)

Supplier: Southern Biotechnology

Description: Purified Rat IgG2b for use as a standard in ELISA.

Catalog Number: (100245-414)

Supplier: Southern Biotechnology

Description: CD3 is a member of the T cell receptor-associated CD3 complex. The monoclonal antibody CT-3 recognizes a complex of at least three polypeptides of Mr 20, 19, and 17 kDa (two of which are N-glycosylated) on chicken T cells. The antibody also coprecipitates a polypeptide of 90 kDa from digitonin solubilized T cell lysates, which can be reduced to two polypeptides of Mr 50 and 40 kDa.