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OPTEM
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OPTEM
Catalog Number:
(100246-514)
Supplier:
Southern Biotechnology
Description:
CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily glycosylated type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. CD107a is expressed by activated T cells, macrophages, dendritic cells, activated platelets, tonsillar epithelium, and some tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular antigen. LAMP-1 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential where they may increase adhesion to extracellular matrix and endothelium.
Catalog Number:
(100242-112)
Supplier:
Southern Biotechnology
Description:
Low Endotoxin/Azide Free Rat IgG2b for use as a control in flow cytometry, immunohistochemistry, and in vivo assays and as a standard in ELISA.
Catalog Number:
(100245-420)
Supplier:
Southern Biotechnology
Description:
CD4 is a type I transmembrane glycoprotein expressed on approximately 70% of thymocytes, 10% of spleen cells, and 45% of peripheral blood lymphocytes but less than 1% of bursal cells. The monoclonal antibody CT-4 inhibits both PHA- and Con A-induced proliferative responses of splenocytes and PWM-induced IL-2 production. This antibody also reacts with turkey and quail as demonstrated by flow cytometry.
Catalog Number:
(101442-886)
Supplier:
Southern Biotechnology
Description:
c-Kit is a 145 kDa transmembrane receptor-type protein tyrosine kinase encoded by the c-Kit proto-oncogene and is the receptor for stem cell factor (SCF). c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis, and adhesion. The amino acid sequence of chicken c-kit shows 63% identity to mouse c-Kit and exhibits similar expression patterns in RNA blot analysis suggesting similar biological roles.
Catalog Number:
(100244-368)
Supplier:
Southern Biotechnology
Description:
Goat F(ab')2 Anti-Human Kappa-PE antibody with minimal reactivity to mouse proteins for use in flow cytometry assays.
Catalog Number:
(100244-164)
Supplier:
Southern Biotechnology
Description:
CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily glycosylated type I transmembrane protein that constitutes one of the two major sialoglycoproteins on lysosomal membranes that can be used to distinguish lysosomes from other organelles. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains and is a ligand for E-selectin-mediated cell adhesion. CD107a is principally expressed in epithelial cells and macrophages in a variety of organs in normal and beige mutant mice. It may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases.
Catalog Number:
(103258-518)
Supplier:
Southern Biotechnology
Description:
Goat Anti-Human IgG-Alexa Fluor 647 antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, and western blotting assays.
Catalog Number:
(100242-668)
Supplier:
Southern Biotechnology
Description:
Goat Anti-Mouse IgG2c-HRP antibody with minimal reactivity to human proteins for use in ELISA, immunohistochemistry, and western blotting assays.
Catalog Number:
(100242-228)
Supplier:
Southern Biotechnology
Description:
Bcl-xL is a 29 kDa member of the Bcl-2 family of proteins involved in regulation of programmed cell death, or apoptosis. It is found in both soluble and membrane fractions of cellular lysates. Like Bcl-2, Bcl-xL has been demonstrated to block apoptosis which is induced by a variety of stimuli and, under certain conditions, offers greater protection against apoptosis than Bcl-2. While formation of heterodimers with the apoptosis-enhancing protein, Bax does not block the apoptosis-suppressing property of Bcl-xL, heterodimerization with Bad effectively inhibits the protective function of Bcl-xL.
Catalog Number:
(100245-930)
Supplier:
Southern Biotechnology
Description:
CD20 is a 33-37 kDa unglycosylated phosphoprotein. Although not a member of the tetraspanin superfamily of cell surface receptors, it crosses the cell membrane four times. It is expressed on all stages of B cell differentiation except plasma cells. The CD20 molecule is involved in regulation of B cell differentiation presumably via its reported function as a Ca++ channel subunit.
Catalog Number:
(103259-658)
Supplier:
Southern Biotechnology
Description:
Interleukin-25 (IL-25), also known as interleukin-17E (IL-17E), is a 17 kDa protein and member of the IL-17 cytokine family. This cytokine is secreted by a variety of cells including type 2 helper T cells (Th2), bone marrow-derived mast cells, and alveolar macrophages. On target cells, IL-25 can induce the production of several type 2 cytokines including IL-4, IL-5, and IL-13 and implicates a role for this cytokine in type 2 immune response. Studies have linked this cytokine in promoting airway hyperreactivity, limiting pro-inflammatory cytokine production and chronic intestinal inflammation, and providing protective immunity following intestinal helminth infection.
Catalog Number:
(100243-300)
Supplier:
Southern Biotechnology
Description:
CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface concomitant with IgD, and is found on most IgM+IgD+ mature B lymphocytes. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via cross-linking of surface Ig increases CD22 expression. CD22 associates with the B cell receptor (BCR) complex and mediates intercellular adhesion. Its intracellular domain is phosphorylated after antigen receptor cross-linking and is involved in negative regulation of B cell activation.
Catalog Number:
(100243-406)
Supplier:
Southern Biotechnology
Description:
CD30 is a type I transmembrane protein and a member of the tumor necrosis factor receptor superfamily of proteins. Murine CD30 is expressed predominantly in the thymus and it is inducible in mouse splenocytes stimulated with pokeweed mitogen or concanavalin A. In anti-CD3ε-activated spleen cells, CD30 is expressed primarily on the surface of CD8+ T cells with peak expression on days 4 and 5. Stimulation of CD30+ CTL lines with plate-bound anti-CD30 directly signals IL-5 but not IFN-γ production. While these studies demonstrate that CD30 directs cytokine secretion and suggest that CD30 may play a pivotal role in the pattern of cytokine production by T cells, the precise roles of CD30 and its ligand (CD153) in T-cell development have not been clearly defined.
Catalog Number:
(100242-810)
Supplier:
Southern Biotechnology
Description:
PE/CY7 Anti-Mouse IgM antibody for use in flow cytometry assays.
Catalog Number:
(103265-232)
Supplier:
Southern Biotechnology
Description:
Purified Anti-Human Kappa antibody for use in ELISA and flow cytometry assays.
Catalog Number:
(101442-896)
Supplier:
Southern Biotechnology
Description:
Low Endotoxin/Azide Free Anti-Human IgM antibody for use in ELISA, flow cytometry, western blotting, and stimulation assays.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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