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OPTEM
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OPTEM
Catalog Number:
(103264-402)
Supplier:
Southern Biotechnology
Description:
Purified Goat Anti-Mouse IgG(H+L) antibody for use in ELISA assays.
Catalog Number:
(103265-228)
Supplier:
Southern Biotechnology
Description:
Alexa Fluor 647 Anti-Human IgG3 Hinge antibody for use in flow cytometry, immunohistochemistry, and western blotting assays.
Catalog Number:
(103265-230)
Supplier:
Southern Biotechnology
Description:
Alexa Fluor 555 Anti-Human IgG3 Hinge antibody for use in immunohistochemistry and western blotting assays.
Catalog Number:
(103265-460)
Supplier:
Southern Biotechnology
Description:
ApoScreen® Annexin V (SB Cat. No. 10040) is a recombinant protein that is expressed in E. coli. A number of changes in cell structure occur during apoptosis. One major change is the loss of membrane phospholipid asymmetry, with translocation of phosphatidylserine (PS) from the inner leaflet of the phospholipid bilayer to the external surface. Annexin V, a member of the annexin family of calcium-dependent phospholipid binding proteins, has a high affinity for phosphatidylserine (PS)-containing phospholipid bilayers. Conjugated Annexin V can be used to monitor changes in cell membrane phospholipid asymmetry, thereby providing a convenient tool for detection of apoptotic cells.
Catalog Number:
(103265-276)
Supplier:
Southern Biotechnology
Description:
CD61 is the integrin β3 subunit, a 110 kDa transmembrane glycoprotein expressed on platelets, megakaryocytes, and endothelial cells. Integrin β3 associates with gpIIb (CD41) to form the CD41/CD61 complex that mediates platelet adhesion and aggregation. CD61 also associates with CD51 to form the αVβ3 vitronectin receptor.
Catalog Number:
(103259-692)
Supplier:
Southern Biotechnology
Description:
Rat IgG1-Alexa Fluor 647 for use as a control in flow cytometry and immunocytochemistry assays.
Catalog Number:
(103259-790)
Supplier:
Southern Biotechnology
Description:
Goat Anti-Mouse IgG2a-Biotin antibody antibody for use in ELISA, immunohistochemistry / immunocytochemistry, and western blotting assays.
Catalog Number:
(103259-890)
Supplier:
Southern Biotechnology
Description:
In the mouse, CD8 exists in two forms – (i) a CD8 heterodimer composed of an α chain (CD8α) and a β chain (CD8β); and (ii) a homodimer of two α chains. The heterodimer is found on the surface of essentially all thymocytes and the “suppressor/cytotoxic” subpopulation of mature T lymphocytes. Subsets of intestinal intraepithelial lymphocytes express CD8α without CD8β. It has been suggested that CD8+β- T cells mature extrathymically, while development of the CD8α+β+ population of T cells is thymus-dependent. CD8 acts as a coreceptor with MHC Class I-restricted T cell receptors in antigen recognition and positive selection of MHC class I-restricted CD8+ T cells. In vivo and in vitro treatment with the 53-6.7 monoclonal antibody effectively depletes CD8α+ cells. The 53-6.7 monoclonal antibody also blocks allogeneic help specific for class I MHC antigens and T cell responses to IL-2.
Catalog Number:
(103259-792)
Supplier:
Southern Biotechnology
Description:
Purified Goat Anti-Mouse IgG2a antibody with minimal reactivity to human, bovine, and horse serum proteins for use in ELISA assays.
Catalog Number:
(103259-672)
Supplier:
Southern Biotechnology
Description:
Interleukin-21 (IL-21) is a four helical bundle type I cytokine. The mature form of human IL-21 is a 131 amino acid protein. IL-21 is expressed primarily by NKT and CD4+ T cells, particularly the inflammatory Th17 subset, and has pleiotropic effects on both innate and adaptive immune responses. The effects of IL-21 include promotion of antibody production, NK cell differentiation, proliferation and differentiation of cells of monocyte and granulocyte lineages, costimulation of T cells, and augmentation of antitumor activity of CD8+ T cells. Studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.
Catalog Number:
(103259-886)
Supplier:
Southern Biotechnology
Description:
CD5, also known as Lyt-1, is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B-cell antigen CD72. The frequency of CD5+ B cells exhibits strain-dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B-1 cells. Binding of CD5 on the T cell surface can augment alloantigen- or mitogen-induced lymphocyte proliferation and induces increased cytosolic free calcium, IL-2 secretion, and IL-2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T-cell and B-cell receptors.
Catalog Number:
(100245-654)
Supplier:
Southern Biotechnology
Description:
FITC Anti-Human IgM antibody for use in flow cytometry and western blotting assays.
Catalog Number:
(100245-250)
Supplier:
Southern Biotechnology
Description:
Purified Donkey Anti-Mouse IgG(H+L) antibody with minimal reactivity to human serum proteins for use in ELISA, flow cytometry, and immunohistochemistry / immunocytochemistry assays.
Catalog Number:
(100243-560)
Supplier:
Southern Biotechnology
Description:
CD45RC represents an exon C-dependent isoform of CD45 glycoprotein. It is expressed at high density on all B lymphocytes, at intermediate density on most CD8+ splenic T cells, and on two subpopulations of CD4+ splenic T cells with high and low density of expression. CD45RC is also present on a small subset of thymocytes.
Catalog Number:
(100244-636)
Supplier:
Southern Biotechnology
Description:
Low Endotoxin/Azide Free F(ab')2 Anti-Rat IgM antibody for use in flow cytometry, ELISA, and stimulation assays.
Catalog Number:
(100246-060)
Supplier:
Southern Biotechnology
Description:
CD4 is a 55 kDa type I transmembrane glycoprotein and a member of the Ig-SF of cell surface receptors. It is expressed predominantly on the “helper/inducer” subpopulation of mature T lymphocytes and on monocytes and macrophages. Domains 1 and 2 bind to MHC Class II antigens, while domains 3 and 4 may be involved in cis interactions with the CD3/TCR complex. CD4 functions as an accessory molecule in the recognition of foreign antigens in association with MHC class II antigens by T cells.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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