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DIAGNOSTIC BIOSYSTEMS INC
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DIAGNOSTIC BIOSYSTEMS INC
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to a Sialoglycoprotein of 27 to 32 kDa known as CD99 or MIC2 gene product. CD99 is expressed on the cell membrane of some lymphocytes, cortical thymocytes and granulosa cells of the ovary, Sertoli cells of testis, pancreatic islet cells and some endothelial cells. Mature granulocytes express very little or no CD99.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with a 65 kDa protein known as Cdc25A. The activity of cyclin-dependent kinases in cell cycle is regulated by the phosphorylation status, which is controlled by the antagonistic action of wee 1 kinase and Cdc25 phosphatases. Three CDC25 genes are present in human cells: CDC25A, CDC25B and CDC25C. Cdc25A and Cdc25B are expressed throughout the cell cycle, with peak expression in G1 for Cdc25A and in both G1-S phase and G2 for Cdc25B. Cdc25C is mainly expressed in G2 phase.
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to 21 kDa protein known as TIMP-2. TIMP-1 and TIMP-2 are inhibitory enzymes of matrix metalloproteinase family. TIMP are of great importance in the maintenance of connective tissue integrity. TIMP-2 shows the highest binding affinity to both the latent (pro) and active forms of 72 kDa Type IV collagenase (MMP-2) and active form of 92 kDa type IV collagenase (MMP-9). TIMP inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
Supplier:
Diagnostic Biosystems
Description:
The clone F7.2.38 is specific for the non-glycosylated epsilon chain of the human CD3 molecule. Clone F7.2.38 recognizes T cells in the thymus, bone marrow, peripheral lymphoid tissue and blood and is a pan T cell marker. The CD3 molecule consists of five different polypeptide chains with molecular weights ranging from 16 to 28 kD. The CD3 antigen is first detected in early thymocytes and its appearance probably represents one of the earliest signs of commitment to the T cell lineage.
Catalog Number:
(99990-968)
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts specifically with a 32 kDa protein similar to the CD8 molecule
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to a 40 kDa protein, which is identified as thyroid transcription factor (TTF-1). TTF-1 is expressed in epithelial cells of the thyroid gland and lung. TTF-1 stains primary lung adenocarcinoma and small cell carcinoma but does not stain colon and breast carcinoma.
Supplier:
Diagnostic Biosystems
Description:
The common acute lymphoblastic leukemia antigen (CALLA/CD10) is a single-pass type II transmembrane metallo-endopeptidase that cleaves and inactivates a variety of peptide growth factors important for signal transduction including the enkephalins, bombesin and substance P. CD10 is expressed by a number of hematopoietic cells such as immature T and B cells, B cells of the germinal centers of lymphoid follicles and granulocytes. It also reacts with a variety of non-hematopoietic cells, including epithelial cells in GI tract and kidney tubular. In liver, the bile canaliculi shows a moderate to strong staining. CD10 has been used for the identification and classification of certain types of malignant lymphoma and leukemia. CD10 is expressed in a high percentage of cases of acute lymphoblastic leukemia, follicular lymphoma, Burkitt's lymphoma, some hematopoietic tumors, and chronic myelogenous leukemias in lymphoid blast crisis. It is also known to be a marker of endometrial stromal cells. It is helpful in differentiating endometrial stromal sarcoma (ESS) from uterine cellular leiomyoma (UCL) and uterine leiomyosarcoma (ULS).
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with a 34 kDa protein known as calponin. Calponin, a calmodulin, binds tropomyosin and F-actin and is thought to be involved in the regulation of smooth muscle contraction. Expression of calponin is restricted to smooth muscle cells. Two isoforms of calponin exist whose molecular weights are 34 KD and 29 kDa. 29 kDa isoform is primarily restricted to the muscle of the urogenital tract.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with a 160 kDa (unreacted dimer) and 80 kDa (reduced monomer) protein. Factor XIII is a β-globulin found in plasma and is composed of two subunits, Factor XIII-A and Factor XIII-B. Factor XIII-A is the catalytic subunit and is a dimer of M.W. 160 kDa. Factor XIII is a dermal dendrocyte marker and shows variable reaction with these types of tumors. Factor XIII can be used for histiocytic phenotyping and has been reported to mark capillary hemangiomas and tumors of the central nervous system.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with a 92 kDa pro form and 86 kDa active form of MMP-9. MMPs are proteolytic enzymes capable of degrading connective tissue components. MMPs play a crucial role in tumor cell invasion and metastasis.
Catalog Number:
(76634-890)
Supplier:
Diagnostic Biosystems
Description:
Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNAbinding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to a 55 kDa protein known as platelet-derived endothelial growth factor (PD-ECGF), or thymidine phosphorylase (TP). High levels of TP/PD-ECGF are observed in cancer patients. High intracellular levels of TP/PD-ECGF are associated with increased sensitivity to fluoropyrimidine chemotherapeutic agents.
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to α-smooth muscle isoform of actin. It reacts with smooth muscle cells of vessels and different parenchyma. This antibody does not cross-react with β and γ-cytoplasmic, α-sarcomeric and α-myocardial actin isoforms.
Supplier:
Diagnostic Biosystems
Description:
This antibody recognizes a protein of 67 kDa, which is identified as estrogen receptor (ER). ER content of breast cancer tissue is an important parameter in the prediction of prognosis and response to endocrine therapy. This antibody strongly stains the nucleus of epithelial cells in breast carcinomas. The ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy.
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific against an epitope located on the β chain (i.e. in S-100a and S-100b) but not on the α chain of S-100 (i.e. in S-100a and S-100ao). This antibody can be used to localize S-100a and S-100b in various tissue sections.
Catalog Number:
(76634-558)
Supplier:
Diagnostic Biosystems
Description:
PTEN gene is a tumor suppressor gene that maps to chromosome 10q23. PTEN, a novel tumor suppressor, functions as a regulator of both cell cycle progression and apoptosis ). Potentially, mutation and deletion of PTEN gene may result in a new signal transduction pathway related to human malignant tumors. Studies have demonstrated a reduction of PTEN expression in advanced breast cancers.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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