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DIAGNOSTIC BIOSYSTEMS INC
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DIAGNOSTIC BIOSYSTEMS INC
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to erythroid cells at various stages of differentiation from the erythroblast to the mature red cell.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with free as well as bound kappa light chains. Contaminating antibodies have been removed by solid phase adsorption.
Supplier:
Diagnostic Biosystems
Description:
The antibody is specific against human α-1-antitrypsin. This antibody stains macrophages in human tissues and does not stain any other cell type.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with a protein of 60 kDa. E2Fs are DNA-binding proteins, which associate with negative regulators, such as the retinoblastoma P107 protein, resulting in an altered rate of gene transcription. E2F-1 is proposed to be involved in several cellular processes that range from tumor suppression, cell progression and oncogenesis. E2F-1 over expression can also drive cells into apoptosis.
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to a 48 kDa protein, which is identified as cytokeratin 16. Cytokeratin 16 is expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region. High concordance was found between the carcinomas immunostaining with the basal cell and the hyperproliferation-related keratins.
Supplier:
Diagnostic Biosystems
Description:
CD138, also known as Syndecan-1, is a member of the transmembrane heparan sulfate proteoglycan family, acts as an extracellular matrix receptor and is involved in many cellular functions, including cell-cell adhesion and cell-matrix adhesion. CD138 expression is found in both hematopoietic and non-hematopoietic cells. In the hematopoietic system, CD138 labels plasma cells. It is an excellent marker for plasmacytic differentiation within the spectrum of hematologic malignancy. Among non-hematolymphoid cells, CD138 reactivity is observed in many types of epithelial cells and stoma cells in both normal and tumor tissues.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with P. carinii in the fixed human tissues. The antibody is specific against an 82 kDa parasite specific polypeptide. It does not cross-react with G. lamblia, T. gondii, T. cruzi, L. tropica, E. histolytica, C. albicans and P. falciparum.
Supplier:
Diagnostic Biosystems
Description:
This antibody stains with S-100 protein. S-100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. S-100a and S-100b proteins are two members of the S-100 family. S-100a is composed of an α and β chain whereas S-100b is composed of two β chains. This antibody stains schwannomas, ependymomas, astrogliomas, almost all benign and malignant melanomas and their metastases.
Catalog Number:
(76634-316)
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with an antigen expressed by normal and neoplastic T cells and myeloid lineage cells. It strongly stains T cells in the interfollicular areas of normal lymphoid tissues.
Supplier:
Diagnostic Biosystems
Description:
MSH6 is a heterodimer of MSH2 and binds to DNA containing G/T mismatches. The MSH2-MSH6 complex recognizes a single-base mispair insertion/deletion loop. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. Studies have shown the mutations of MLH-1, MSH2 and MSH6 genes contribute to the development of sporadic colorectal carcinoma. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time.
Supplier:
Diagnostic Biosystems
Description:
This antibody recognizes keratin polypeptides of 68, 58, 56.5 and 50 kDa in the stratum corneum. The antibody reacts with squamous, ductal and other complex epithelia. It stains adenocarcinomas, breast, pancreas, bile duct, salivary gland and transitional cell carcinomas.
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to a 32 kDa protein, which is identified as Caspase 3. Caspase 3 is associated with induction of apoptosis. Caspase 3 is ubiquitously expressed and is synthesized as an inactive proenzyme.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with β-amyloid protein. This antibody stains amyloid plaques within the cortex, and amyloid deposits in blood vessels. β-amyloid deposits are also detected in Lewy body dementia, Down syndrome, amyloidosis and in Gram-Parkinson dementia complex. The presence of a large number of neuritic plaques (senile) and neurofibrillary tangles in the cerebral cortex is used as a pathological marker for a disease state and presents the major criterion for the diagnosis of Alzheimer’s disease at autopsy.
Supplier:
Diagnostic Biosystems
Description:
ERG, the ETS related gene, belongs to the ETS family that plays important roles in cell development, differentiation, proliferation, apoptosis and tissue remodeling. The ERG antibody identifies endothelial cells, lymphocytes and prostate cancer cells.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with the 57 kDa intermediate filament protein present in the cells of mesenchymal origin. The antibody does not show any cross-reactivity with other intermediate filament proteins. However, it shows a broad interspecies cross-reactivity.
Supplier:
Diagnostic Biosystems
Description:
Chromogranin A is a 439 amino acid protein present in secretory granules of a wide variety of endocrine cells and neurons. A positive staining is seen in the secretory granules of parathyroid, adrenal medulla, anterior pituitary gland and Langerhans islets of pancreas. This antibody stains a variety of neuroendocrine tumors.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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