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DIAGNOSTIC BIOSYSTEMS INC
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with Von Willebrand factor in endothelial cells. It also reacts with megakaryocytes in human bone marrow.
Supplier:
Diagnostic Biosystems
Description:
This antibody recognizes CD5, which is a transmembrane protein, is found on 95%of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is expressed by many T cell leukemia, lymphomas, and activated T cells. Occasionally, CD5 antigen is also expressed on a subset of B cells. Mantle cell lymphomas (same as diffuse centrocytic lymphomas) are CD5(+) while the follicle center cell lymphoma are CD5(-).
Catalog Number:
(10065-090)
Supplier:
Diagnostic Biosystems
Description:
The combined detection of p504S, p40 and high molecular weight cytokeratin markers has been shown to be useful for distinguishing benign conditions mimicking cancer from prostate carcinomas. In particular, these markers have been shown to be relevant in diagnosing the premalignant condition, prostatic intraepithelial neoplasia (PIN). High molecular weight cytokeratin and p63 are commonly used markers of basal epithelial cells. Benign prostate tissue contains basal cells, which are absent in prostate cancers. As p40 is an isoform of p63, it also stains basal epithelial cells and can be used in prostate cancer tissue. P504S has been recently described as a prostate cancer-specific gene. Expression of p504S (AMACR) protein is seen in prostatic adenocarcinoma but not in benign prostatic tissue. Anti-p540S stains premalignant lesions of prostate: high-grade PIN and atypical adenomatous hyperplasia. The PIN5 antibody combination may be particularly useful for confirming the diagnosis of prostate carcinoma in small foci of needle biopsies. The positive prostate cancer marker, p504S (AMACR), in conjunction with the negative basal cell markers (p40 and HMW cytokeratin) offers utility in diagnosing PIN in difficult cases where tissue may be limited.
Catalog Number:
(99990-154)
Supplier:
Diagnostic Biosystems
Description:
RTU HRP label for IHC.
Catalog Number:
(99991-136)
Supplier:
Diagnostic Biosystems
Description:
Clone number SP7. The CD3 antigen is present on early thymocytes and mature T cells and is generally regarded as a Pan T cell marker. This rabbit monoclonal antibody will help detect CD3 expression in normal and neoplastic tissues. This antibody reacts with the intracytoplasmic portion of the CD3 antigen expressed by T cells.
Supplier:
Diagnostic Biosystems
Description:
This antibody recognizes thyroglobulin in hyperplastic and neoplastic thyroid. Thyroglobulin is a protein of 670 kDa consisting of two identical subunits. Thyroglobulin is synthesized by the follicular epithelial cells of the thyroid.
Catalog Number:
(99990-032)
Supplier:
Diagnostic Biosystems
Description:
This antibody is well suited for tissue section staining but may also be used for other applications.
Supplier:
Diagnostic Biosystems
Description:
PermaRed/AP is a substrate chromogen system for use with alkaline phosphatase (AP) detection in immunohistochemistry (IHC) or<i> in situ</i> hybridizations (ISH).
Supplier:
Diagnostic Biosystems
Description:
This AE1/AE3 antibody cocktail recognizes most of the acidic (Type I) keratins as well as basic (Type II). It recognizes keratin polypeptides of 40, 48, 50, 52, 54, 56.5, 58, 59 and 64 to 67 kDa. In keratinized epidermis, 50 kDa keratin is present in the basal layer, while 56.5 kDa keratin is present in suprabasal layers. 58 kDa keratin is present in the basal and suprabasal layers, while 65 to 67 kDa keratin is present in the cells above the basal layers. This antibody can be used to stain distinct cell layers in an epithelial tissue and various neoplasms of epithelial origin.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with mast cells distributed in skin, synovium, lung, and heart. This antibody does not bind with any other cell type. Mast cells contain a number of preformed chemicals mediators such as histamine, chymase, carboxypeptidase, and proteolytic tryptase. Human mast cell tryptase is considered to be an important marker of mast cell activation and is an important mediator of inflammation.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with desmin protein of 53 kDa. Both striated as well as smooth muscle cells stain well with this antibody. The antibody shows a broad interspecific cross-reactivity, reacting with human.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with the 54 kDa (flagellin) of <i>H. pylori.</i> The antibody stains the bacteria present on the surface of the epithelium or in the cytoplasm of the epithelial cells. <i>H. pylori</i> is known to cause peptic ulcer and chronic gastritis in humans.
Catalog Number:
(76633-446)
Supplier:
Diagnostic Biosystems
Description:
This antibody recognizes heavy chain of human skeletal myosin. It does not stain cardiac or smooth muscle myosin. This antibody stains the fast twitch (type II) isomyosin molecule.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with chains of human IgA. This antibody has been adsorbed to a very high level of specificity.
Supplier:
Diagnostic Biosystems
Description:
This antibody stains with HPV type 16. L1 protein is a major capsid protein of HPV type 16. HPV 6 and 11 have been associated with relatively benign diseases such as genital warts but type 16 and 18 are strongly associated with cervical, vaginal and vulvar malignancies.
Supplier:
Diagnostic Biosystems
Description:
Alpha Fetoprotein (AFP) is a single chain glycoprotein of 70 kDa that is normally expressed in the fetal liver, gastrointestinal tract and yolk sac. This antibody recognizes an epitope of α-fetoprotein present in human and several other species.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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