Van Der Voort Lucht en Milieu Amste
Catalog Number:
(102512-732)
Supplier:
Adipogen
Description:
Glucocorticoid induced TNF receptor family related gene (GITR; AITR) is a type 1 228 amino acid transmembrane protein that has been designated TNFRSF18. GITR is expressed mainly by CD4+ CD25+ T lymphocytes. Its engagement by antibodies or its ligand (GITRL) induces a costimulatory signal which can break T cell suppression. GITR has been implicated as a regulatory mechanism in anti-parasitic immune resposes, and is involved with macrophages activation in atherosclerotic plaque formation.
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Supplier:
Adipogen
Description:
Fluorescent dye (label, probe, stain).
Catalog Number:
(102979-292)
Supplier:
Adipogen
Description:
Oxidative damage to lipids (lipid peroxidation) has been found to play an important role in various disease and aging processes. During early stages of lipid peroxidation, lipid hydroperoxides (LOOH) are formed. These can react additionally to form later stage end products such as malondialdehyde (MDA) and hydroxynonenal (HNE). LOOH is measured to quantify early stage or acute lipid peroxidation while MDA is commonly measured to quantify late stage or chronic lipid peroxidation. More recently, it has been reported that 13-hydroperoxyoctadecanoic acid (13-HPODE), a precursor to 13-hydroxyoctadecanoic acid (13-HODE) can react with proteins to form measurable adducts by covalently binding to specific amino acid residues. The Hexanoyl-Lysine (HEL) adduct is formed upon oxidative modification of omega-6 fatty acids such as linoleic acid, the predominant polyunsaturated fatty acid (PUFA) in the human diet, and arachidonic acid. HEL may be another useful biomarker for detecting and quantifying the earlier stages of lipid peroxidation.
Supplier:
Adipogen
Description:
Anti-inflammatory and anti-arthritic agent
Catalog Number:
(102512-510)
Supplier:
Adipogen
Description:
Human CD60 antigen is a glycolipid determinant found on about 30% of peripheral blood T cells. The glycolipid determinant is linked to a glycoprotein which can transduce activation signals.
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Catalog Number:
(102988-356)
Supplier:
Adipogen
Description:
Antidiabetic agent. Potent and selective partial agonist of peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear receptor regulating lipid and glucose metabolism. Has nanomolar binding affinity to PPARgamma and micromolar binding to the isotypes PPARalpha and PPARbeta/delta. Glucose-lowering agent. Improves insulin sensitivity, glucose tolerance and blood lipid variables without increase of fat storage or hepatoxicity. Shows potent PPARgamma-dependent anti-inflammatory activity. Potent NF-kappaB activation inhibitor by the suppression of IkappaBalpha degradation, p65 nuclear translocation and DNA-binding activity. Antimicrobial agent.
Catalog Number:
(102512-940)
Supplier:
Adipogen
Description:
Human CD98 (4F2) is a heterodimeric glycoproein expressed on monocytes and activated cells. All cultured human cell lines tested express CD98. CD98 heavy chain mediates adhesion induced activation through integrin signaling.
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Supplier:
Adipogen
Description:
Polylactides (PLA) used in material sciences. Polymer. Lactide and Glycolide Polymers.
Catalog Number:
(102512-214)
Supplier:
Adipogen
Description:
Human CD30 is a member of the TNF receptor family and is expressed on mitogen activated B and T cells.
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Supplier:
Adipogen
Description:
Hydroxy fatty acid used to study its role in biological processes such as oxidative stress, inflammation and insulin resistance. Used in endotoxin and lipid A research, since it is one of two major components of bacterial Lipid A. Shows antifungal activity. Compound could be used as analytical reference in assaying food samples.
Supplier:
Adipogen
Description:
Intercalating probe for nucleic acids. Other applications include the determination of cationic surfactants.
Supplier:
Adipogen
Description:
Potent STING ligand. Second messenger in human and mouse cells that triggers interferon production in response to cytosolic DNA. Binding to STING leads to activation of IRF3 (IFN regulatory factor 3) and the induction of interferon-beta. First cyclic nucleotide in metazoa. Plays a role in bacterial chemotaxis and colonization.
Supplier:
Adipogen
Description:
Fluorogenic substrate for esterase and lipase.
Catalog Number:
(102513-540)
Supplier:
Adipogen
Description:
Phytotoxin. Microtubule assembly inhibitor. Similar to curvularin.
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Catalog Number:
(102512-844)
Supplier:
Adipogen
Description:
Human IgG1kappa from human myeloma plasma is used as a negative control for work involving human IgG1 isotype antibodies or recombinant proteins.
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Supplier:
Adipogen
Description:
The transmembrane and secreted protein delta-like 1 homolog (DLK1; Protein delta homolog 1; Preadipocyte factor 1; Pref-1) belongs to the EGF-like family. It can be cleaved by a tumor necrosis factor-alpha converting enzyme (TACE) to release a soluble form. DLK1 plays important roles in regulating cell differentiation such as adipogenesis and osteogenesis. Membrane-bound DLK1 promotes hypertrophic myotube formation, whereas soluble DLK1 inhibits myotube formation. The soluble form of DLK1 inhibits preadipocyte differentiation, while membrane DLK1 represses preadipocyte proliferation. DLK1 is also associated with tumor invasion.
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