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Van Der Voort Lucht en Milieu Amste
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Van Der Voort Lucht en Milieu Amste
Catalog Number:
(102513-156)
Supplier:
Adipogen
Description:
Human CD165 is a cell surface molecule present on a subset of peripheral lymphocytes and monocytes and is important for adhesion of thymocytes to thymic epithelial cells.
Catalog Number:
(102512-090)
Supplier:
Adipogen
Description:
Human CD18 (beta integrin) forms a heterodimer with either alphaL, alphaM, or alphaX integrins (CD11a, b or c). CD11/CD18 heterodimeric molecules are involved with cell/cell and cell/extracellular adhesion in immune and inflammatory responses.
Catalog Number:
(102981-534)
Supplier:
Adipogen
Description:
CD278, also called inducible costimulator (ICOS) or CRP1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS is expressed on most CD45RO+ cells. ICOS expression is upregulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.
Catalog Number:
(102513-334)
Supplier:
Adipogen
Description:
The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines, and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.
Catalog Number:
(102979-930)
Supplier:
Adipogen
Description:
Asc promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. It is a component of the inflammasome, a protein complex which also includes NLRP3/NALP3, CARD8 and CASP1 and whose function is the activation of proinflammatory caspases.
Catalog Number:
(102979-946)
Supplier:
Adipogen
Description:
IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.
Catalog Number:
(102512-594)
Supplier:
Adipogen
Description:
Human CD75 is an alpha 2, 6-sialylated carbohydrate molecule found mainly on mature B cells and germinal center B cells and also in T cell subsets and erythrocitic cells. CD75 appears to be a ligand for CD22.
Supplier:
Adipogen
Description:
Major capsaicinoid. TRPV1 and hTRPA1 agonist. Shown to activate capsaicin receptor, also called transient receptor potential vanilloid subfamily member 1 (TRPV1), but without inducing a nociceptive response. Anti-inflammatory and anticancer compound.
Supplier:
Adipogen
Description:
Induces neuritogenesis. Potent and selective irreversible proteasome inhibitor. Specifically inhibits 20S proteasome (MCP; multicatalytic complex). Blocks proteasome activity by targeting the catalytic beta-subunit. Apoptosis inducer. Anticancer compound. Upregulates HSP70 and HSP22. Induces differentiation and inhibits cell cycle progression in several tumor cell lines. Inhibits NF-kappaB activation by inhibiting IkappaB degradation. Cathepsin A inhibitor. beta-Secretase activity inhibitor. Anti-adipogenic. Autophagy inducer.
Catalog Number:
(102513-034)
Supplier:
Adipogen
Description:
Human CD134 (OX40; ACT35) is an activation-associated antigen which is predominantly expressed on activated CD4 positive cells. CD134 antigen is a member of the TNF receptor family of molecules and may be involved with regulating T cell-dependent B cell proliferation and differentiation.
Supplier:
Adipogen
Description:
Radicicol is an antibiotic, protein tyrosine kinase inhibitor.
Supplier:
Adipogen
Description:
Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GD1a is the major ganglioside of the nervous system. It is converted to GM1 by bacterial, viral and mammalian sialidases. It is a differentiation marker for cell growth.
Supplier:
Adipogen
Description:
Amine used as chiral and organic building block.
Supplier:
Adipogen
Description:
Mitochondria-derived peptide (MDP). Promotes biosynthesis of the endogenous AMP analog AICAR and consequently AMP-activated protein kinase (AMPK). Induces cellular and systemic glucose uptake and improves insulin sensitivity. Shown to prevent diet-induced obesity (DIO) in mice. Potential anti-obesity and anti-aging compound.
Supplier:
Adipogen
Description:
BX912 is a PDK1 (3-Phosphoinositide-dependent Kinase-1) inhibitor, with an IC(50) of 26nM.
Supplier:
Adipogen
Description:
Amino derivative of biotin that can be used as an intracellular label for cells, particularly neurons. It is used for neuronal tracing studies by visualizing neural architecture and for the identification of gap junction coupling. It is better soluble and non-toxic compared to other neuronal labels. It remains longer in cellsand can be fixed with formalin or glutaraldehyde. It can be detected using avidin or streptavidin systems with either chromogenic or fluorescence visualization methods.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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