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CAYMAN CHEMICAL COMPANY, INC.
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CAYMAN CHEMICAL COMPANY, INC.
Supplier:
Cayman Chemical Company
Description:
A simple, reproducible, and sensitive tool for assaying free thiol content in samples.
Catalog Number:
(75817-192)
Supplier:
Cayman Chemical Company
Description:
A colorimetric assay for the screening of isozyme-specific inhibitors.
Supplier:
Cayman Chemical Company
Description:
For the quantification of PGF<sub>2α</sub> in tissue culture supernatants and other sample matrices.
Supplier:
Cayman Chemical Company
Description:
For the rapid measurement of PGEâ‚‚ from biological samples.
Supplier:
Cayman Chemical Company
Description:
RO8191, Purity >/=98%, CAS 691868-88-9, MF: C14H5F6N5O, MW: 373.2, Synonyms: Ro 494-8191, 8-(1,3,4-oxadiazol-2-yl)-2,4-bis(trifluoromethyl)-imidazo[1,2-a][1,8]naphthyridine, Formulation: A crystalline solid, Storage: -20C, Size: 25mg
Supplier:
Cayman Chemical Company
Description:
Dimethyl biphenyl-4,4'-dicarboxylate, Purity >/=95%, CAS 792-74-5, MF: C16H14O4, MW: 270.3, Synonyms: Biphenyl dimethyl dicarboxylate, 4,4'-dimethyl ester [1,1'-biphenyl]-4,4'-dicarboxylic acid, Size: 50g
Catalog Number:
(76544-222)
Supplier:
Cayman Chemical Company
Description:
A Certified Reference Material
Catalog Number:
(76544-380)
Supplier:
Cayman Chemical Company
Description:
A Certified Reference Material
Catalog Number:
(76544-456)
Supplier:
Cayman Chemical Company
Description:
A Certified Reference Material
Catalog Number:
(76293-148)
Supplier:
Cayman Chemical Company
Description:
Stimulator of interferon genes (STING) is a component of the innate immune response that binds to cyclic dinucleotides, which are bacterial second messengers, leading to activation of NF-κB and transcription of immunomodulatory genes, including type I interferon (IFN). The R232 variant is the most common variant in the human population, found at a frequency of 57.9% in the 1000 Genome Project.{38697} The SNP variant H232 (Item No. 22815) is found at a 13.7% frequency. Various mutations in STING either reduce or increase its activity. Gain-of-function mutations in STING, including R284M (Item No. 23594) and V155M, lead to constitutive activation and enhancement of the type I IFN response. The V155M mutation is associated with a systemic inflammatory condition, including pulmonary fibrosis and autoimmune factors. Mutations that reduce STING activity include K224R (Item No. 23593), which reduces ubiquitination of STING thereby disrupting its localization within the cell, and the double mutation G230A, R293Q (Item No. 23592), which reduces the IFN response. A T596A mutation present in the mouse strain Goldenticket leads to a complete loss of STING protein and lack of a type I IFN response to infection by <em>Listeria</em>.
Catalog Number:
(76544-506)
Supplier:
Cayman Chemical Company
Description:
A Certified Reference Material
Catalog Number:
(76544-104)
Supplier:
Cayman Chemical Company
Description:
A Certified Reference Material
Catalog Number:
(76292-892)
Supplier:
Cayman Chemical Company
Description:
Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a nucleotidyltransferase located in the cytosol that acts as a cytosolic DNA sensor to detect foreign DNA from microbial pathogens as part of the innate immune response. Upon binding to cytosolic DNA, cGAS produces the cyclic dinucleotide second messenger cGAMP, which activates (STING), leading to activation of the type I interferon (IFN) pathway. <em>In vitro</em>, fibroblasts, macrophages, and dendritic cells isolated from cGAS knockout (cGAS<sup>-/-</sup>) mice do not produce type I IFNs following DNA transfection or DNA virus infection. Similarly, cells containing a frame-shift mutation in the cGAS locus fail to mount an immune response to HIV and other retroviruses. <em>In vivo</em>, cGAS<sup>-/-</sup> mice infected with herpes simplex virus 1 (HSV-1) have lower levels of IFN-α and IFN-β, shorter survival times, and higher post-mortem levels of HSV-1 in the brain.
Catalog Number:
(76544-332)
Supplier:
Cayman Chemical Company
Description:
A Certified Reference Material
Catalog Number:
(76304-458)
Supplier:
Cayman Chemical Company
Description:
STING M284 variant Monoclonal Antibody, Clone: 8E7, Host: Mouse, Reactivity: Human, Isotype: IgG1, Immunogen: Synthetic peptide from the internal region of human STING protein containing the R284M mutation, Synony
Catalog Number:
(76544-560)
Supplier:
Cayman Chemical Company
Description:
A Certified Reference Material
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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