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Supplier:
Adipogen
Description:
Antineoplastic, anti-inflammatory and immunomodulating agent. Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50=322nM). Affects DC differentiation and function, leading to impaired T cell activation. Used in the treatment of myeloproliferative neoplasms and psoriasis. Anticancer agent. Shown to induce apoptosis and autophagy. Potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro.
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
3-Amino-5-ethyl-1H-pyrazole 97%
Supplier:
Adipogen
Description:
Aurora kinases are key regulators of protein phosphorylation during mitosis, and these serine/threonine kinases interact with other cellular proteins to help control chromosome assembly and segregation during mitosis. Aurora kinases are often highly expressed in malignancies and solid tumors. Danusertib (PHA-739358) is a small molecule pan- Aurora kinase inhibitor that also has activity against other cancer-relevant kinases such as Bcr-Abl tyrosine kinase. Other off target effects of danusertib include inhibition of receptor tyrosine kinases such as FGFR-1, and TrkA. Danusertib demonstrates nanomolar IC(50) values for the Aurora kinases all under 100nM and it also demonstrates potent anti-proliferation effects in cell proliferation assays with IC(50) values ranging from 20nM for A2780 cells to <lt/>200nM.
Supplier:
Matrix Scientific
Description:
MF=C8H9N3 MW=147.18 Cas=90223-02-2 MDL=MFCD03787880 5G
Supplier:
AMBEED, INC
Description:
6-(tert-Butyl)-2-(furan-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid, Purity: 98%, CAS Number: 407587-33-1, Appearance: Form: solid, Storage: Keep in dark place, Inert atmosphere, Store in freezer, under -20C, Size: 25MG
Supplier:
TCI America
Description:
CAS Number: 4702-13-0
MDL Number: MFCD00005900 Molecular Formula: C10H7NO4 Molecular Weight: 205.17 Purity/Analysis Method: >98.0% (HPLC,T) Form: Crystal Color: White Melting point (°C): 196
Supplier:
TCI America
Description:
CAS Number: 33512-26-4
MDL Number: MFCD00134313 Molecular Formula: C13H16NO5P Molecular Weight: 297.25 Purity/Analysis Method: >98.0% (GC) Form: Crystal Color: White Melting point (°C): 63
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
EDTA tripotassium salt dihydrate 99+%
Catalog Number:
(AAAL12128-14)
Supplier:
Adipogen
Description:
PD173955 is an ATP-competitive, dual Src/Bcr-Abl kinase inhibitor. It is a potent inhibitor of Bcr-Abl with an IC(50) of 1-2nM in kinase inhibition assays. In cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 also inhibits Src kinase activity in vitro with an IC(50) of 22nM and could represent a novel class of anti-mitotic drug.
Catalog Number:
(TS24175-2500)
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
Isoguanine 98%
Supplier:
AMBEED, INC
Description:
tert-Butyl-2-amino-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate 97%
Supplier:
Adipogen
Description:
CX-4945 is a first-in-class, orally active, potent and selective inhibitor of the protein kinase CK2, with an IC(50) of 1nM.
Catalog Number:
(101775-236)
Catalog Number:
(10082-150)
Supplier:
Proteintech
Description:
ADH5, also named as ADHX, FDH FALDH GSH-FDH ADH3 and GSNOR, belongs to the zinc-containing alcohol dehydrogenase family and Class-III subfamily. It is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. ADH5 mediates multiple cardiovascular functions. It plays in regulating heterocellular communication in the artery wall.
Catalog Number:
(10282-048)
Supplier:
Bioss
Description:
ADH6 (alcohol dehydrogenase 6), also known as ADH-5, is a 368 amino acid member of the class V zinc-containing alcohol dehydrogenase family. This family of enzymes functions to metabolize a wide variety of substrates such as retinol, hydroxysteroids, ethanol, aliphatic alcohols and lipid peroxidation products. Localized to the cytoplasm and expressed in the stomach and liver, ADH6 catalyzes the reversible oxidation of alcohols to their corresponding aldehydes or ketones and is able to bind two zinc ions as cofactors. ADH6 contains a glucocorticoid response element upstream of its 5' UTR which is thought to be a steroid binding site, suggesting that expression of ADH6 may be under hormonal control. Multiple isoforms of ADH6 exist due to alternative splicing events.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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