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IKK-2
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IKK-2
Catalog Number:
(103360-060)
Supplier:
Novus Biologicals
Description:
The IKK gamma Antibody (72C627) [DyLight 350] from Novus Biologicals is a mouse monoclonal antibody to IKK gamma. This antibody reacts with human, mouse. The IKK gamma Antibody (72C627) [DyLight 350] has been validated for the following applications: Western Blot.
Catalog Number:
(103274-162)
Supplier:
Novus Biologicals
Description:
The IKK beta Antibody from Novus Biologicals is a rabbit polyclonal antibody to IKK beta. This antibody reacts with human. The IKK beta Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.
Catalog Number:
(102134-084)
Supplier:
Novus Biologicals
Description:
IKK beta Peptide.
Catalog Number:
(76082-116)
Supplier:
Bioss
Description:
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.
Catalog Number:
(103360-042)
Supplier:
Novus Biologicals
Description:
The IKK gamma Antibody (72C627) [DyLight 650] from Novus Biologicals is a mouse monoclonal antibody to IKK gamma. This antibody reacts with human, mouse. The IKK gamma Antibody (72C627) [DyLight 650] has been validated for the following applications: Western Blot.
Supplier:
ANTIBODIES.COM LLC
Description:
Rabbit polyclonal antibody to IKK alpha + IKK beta (phospho Ser176 + Ser180) for WB with samples derived from Human, Mouse and Rat.
Catalog Number:
(77067-942)
Supplier:
ANTIBODIES.COM LLC
Description:
Rabbit polyclonal antibody to IKK-gamma for WB, IHC and ELISA with samples derived from Human.
Catalog Number:
(103359-532)
Supplier:
Novus Biologicals
Description:
The IKK beta Antibody (10A9B6) [DyLight 350] from Novus Biologicals is a mouse monoclonal antibody to IKK beta. This antibody reacts with human, mouse. The IKK beta Antibody (10A9B6) [DyLight 350] has been validated for the following applications: Western Blot, Flow Cytometry, Immunocytochemistry / Immunofluorescence, Flow (Intracellular).
Catalog Number:
(10301-914)
Supplier:
Bioss
Description:
The transcription factor NFkB is retained in the cytoplasm in an inactive form by the inhibitory protein IkB. Activation of NFkB requires that IkB be phosphorylated on specific serine residues, which results in the targeted degradation of IkB (1). IkB kinase alpha (IKK alpha), previously designated CHUK (2), interacts with IkB-alpha and specifically phosphorylates IkB-alpha on the sites that trigger its degradation, serines 32 and 36 (3). IKKalpha appears to be critical for NFkB activation in response to proinflammatory cytokines (4). Phosphorylation of the IkB by IKK alpha is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulator for NFkB activation in response to TNF and IL-1 (5). The functional IKK complex contains three subunits, IKK alpha, IKK beta and IKK gamma (also designated NEMO), and each appears to make essential contributions to IkB phosphorylation (6). IKAP (IKK-complex-associated protein) is a protein that acts as a scaffold, interacting with NIK, IKK alpha and IKK beta and assembling them into an active kinase complex (7,8)
Supplier:
Cayman Chemical Company
Description:
IKK2 Inhibitor VI, Purity >/=95%, CAS 354811-10-2, MF: C12H11N3O2S, MW: 261.3, Synonyms: 5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide, 2-[(aminocarbonyl)amino]-5-phenyl-3-thiophenecarboxamide, Formulation: A crystalline solid, Storage: -20C, Size: 500ug
Catalog Number:
(76744-248)
Supplier:
ANTIBODIES.COM LLC
Description:
Mouse IKK beta ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the <i>in vitro</i> quantitative determination of mouse IKK beta in serum, plasma, tissue homogenates, and other biological fluids.
Catalog Number:
(103359-512)
Supplier:
Novus Biologicals
Description:
The IKK beta Antibody (10A9B6) [Allophycocyanin] from Novus Biologicals is a mouse monoclonal antibody to IKK beta. This antibody reacts with human, mouse. The IKK beta Antibody (10A9B6) [Allophycocyanin] has been validated for the following applications: Flow Cytometry, Flow (Intracellular).
Catalog Number:
(76739-150)
Supplier:
ANTIBODIES.COM LLC
Description:
Human IKK beta ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the <i>in vitro</i> quantitative determination of human IKK beta in serum, plasma, tissue homogenates, and other biological fluids.
Catalog Number:
(89359-198)
Supplier:
Genetex
Description:
NFkB is associated with IkB proteins in the cell cytoplasm, which inhibit NFkB activity. The IkB kinase (IKK) phosphorylates IkB, and mediates IkB degradation and NFkB activation. IKK is a serine protein kinase. The beta subunit is part of the IKK complex.
Catalog Number:
(10362-512)
Supplier:
Bioss
Description:
IKK Alpha/IKK beta is a member of the IKK complex which is composed of IKK alpha, IKK beta, IKK gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK beta has been shown to activate NF-kB and phosphorylate IKB alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK beta is essential for activation of IKK by TNF and IL1. Once activated, IKK beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK beta activity can also be regulated by MEKK1.
Catalog Number:
(10209-426)
Supplier:
Boster Biological Technology
Description:
Rabbit IgG polyclonal antibody for Inhibitor of nuclear factor kappa-B kinase subunit alpha(CHUK) detection. Tested with WB in Human.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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