DIAGNOSTIC BIOSYSTEMS INC
Supplier:
Diagnostic Biosystems
Description:
The caudal-related homeodomain protein 2, CDX-2, is a transcription factor which is expressed in the intestine and is thought to play an important role in the proliferation and differentiation of intestinal epithelial cells. The CDX-2 protein is expressed in primary and metastatic colorectal carcinomas, intestinal metaplasia of the stomach and intestinal type gastric cancer. In human colorectal cancer, the expression of both CDX2 and carbonic anhydrase 1, a gene regulated by CDX2, is reduced or absent. CDX-2 is one of the important regulators in defining pathways for coordinate control of drug metabolism in the gastrointestinal tract.
Catalog Number:
(76634-608)
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to γ-γ enolase isozyme of 46 kDa. This antibody stains neurons, neuroendocrine cells, gangliomas, oat cell carcinomas, astrocytomas, paragangliomas, glioblastomas, pheochromocytomas, melanomas and schwannomas.
Catalog Number:
(76634-606)
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with lysozyme. It stains granulocytes, monocytes and macrophages in human tonsil, skin and colon. This antibody does not cross-react with any other cell types.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with the terminal globular domain of the A chain. The staining with this antibody is sensitive to fixation of paraffin tissues and use of proteolytic enzymatic treatment.
Catalog Number:
(10065-178)
Supplier:
Diagnostic Biosystems
Description:
The Papanicolaou (PAP) Stain Kit is designed to differentiate between a variety of cells in vaginal smears for detection of vaginal, uterine and cervical cancer.
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to a sialoglycoprotein of 27-32 kDa known as CD99 or MIC2 gene product. CD99 is expressed on the cell membrane of some lymphocytes, cortical thymocytes and granulosa cells of the ovary, sertoli cells of testis, pancreatic islet cells and some endothelial cells. Mature granulocytes express very little or no CD99.
Supplier:
Diagnostic Biosystems
Description:
P504S has been recently described as a prostate cancer-specific gene that encodes a protein involved in the β-oxidation of branched chain fatty acids. Expression of p504S protein is found in prostatic adenocarcinoma but not in benign prostatic tissue. It stains premalignant lesions of prostate: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia. P504S can be used as a positive marker for PIN.
Supplier:
Diagnostic Biosystems
Description:
This antibody recognizes a glycoprotein of 110 kDa molecular weight present on human platelets and also reacts with megakaryocytes and megakaryoblasts. The antigen is also present on endothelium and osteoclasts. The glycoprotein IIIa molecule produced by endothelium cells is identical in sequence to platelet glycoprotein IIIa.
Catalog Number:
(76634-858)
Supplier:
Diagnostic Biosystems
Description:
Chromogranin A is a 439 amino acid protein present in secretory granules of a wide variety of endocrine cells and neurons. A positive staining is seen in the secretory granules of parathyroid, adrenal medulla, anterior pituitary gland and Langerhans islets of pancreas. This antibody stains a variety of neuroendocrine tumors.
Supplier:
Diagnostic Biosystems
Description:
This antibody stains a 60 kDa peptide in human lymphoblasts. TdT is present in the cells during immunoglobulin gene rearrangement and plays an important role in lymphocyte maturation. TdT marks both T and B immature lymphocytes normally found in thymus and bone marrow.
Supplier:
Diagnostic Biosystems
Description:
The CD163 molecule is a type I membrane protein also known as M130 antigen, Ber-MAC3, Ki-M8 or SM4. CD163 protein is restricted in its expression to the monocytic/macrophage lineage. It is reported to be present on all circulating monocytes and most tissue macrophages except those found in the mantle zone and germinal centers of lymphoid follicles, interdigitating reticulum cells and Langerhans cells. In addition, multinucleated cells within inflammatory lesions are reported not to express CD163 protein. The protein is upregulated by glucocorticoids and downregulated by the immunosuppressant cyclosporin A and by phorbol esters.
Catalog Number:
(76634-330)
Supplier:
Diagnostic Biosystems
Description:
This antibody recognizes keratin polypeptides of 68, 58, 56.5 and 50 kDa in the stratum corneum. The antibody reacts with squamous, ductal and other complex epithelia. It stains adenocarcinomas, breast, pancreas, bile duct, salivary gland and transitional cell carcinomas.
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to two proteins of 185 kDa and 145 kDa, identified as two isoforms of neural cell adhesion molecules (NCAM/CD56). NCAM is expressed on most neuroectodermal derived cell lines, tissues and neoplasms such as retinoblastoma, medulloblastoma, astrocytoma and neuroblastoma.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts specifically with CA 125 ovarian cancer antigen. Several studies have shown that CA 125 is a useful tumor marker for ovarian epithelial malignancies. However, CA 125 has been described in other neoplasms such as seminal vesicle and anaplastic lymphomas.
Supplier:
Diagnostic Biosystems
Description:
PermaBlue/HRP is a substrate-chromogen system designed to be used for either IHC or ISH when utilizing horseradish peroxidase
Supplier:
Diagnostic Biosystems
Description:
Myeloperoxidase metabolizes most of the hydrogen peroxide generated by activated phagocytes. This antibody stains strongly with the cytoplasm of myeloid cells. The antibody detects myeloperoxidase found in myeloid cells of acute myeloid leukemia. The myeloperoxidase gene has been localized to chromosome 17.
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