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DIAGNOSTIC BIOSYSTEMS INC
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts specifically with B cells at the pre B cell stage. It stains a majority of acute leukemias of precursor B cell type, B cell lymphomas and some myelomas. The mb-1 polypeptide along with B29 polypeptide forms an antigen receptor complex on the B cell, performing signal transduction and phosphorylation functions.
Catalog Number:
(76634-550)
Supplier:
Diagnostic Biosystems
Description:
The homeodomain-containing transcription factor NKX3-1 is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3-1 protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia.
Catalog Number:
(76634-262)
Supplier:
Diagnostic Biosystems
Description:
This antibody is a member of a family of complex antigens, which also includes non-specific cross-reacting antigens (NCA). This antibody stains specific regions of CEA. It reacts with colorectal adenocarcinomas but does not show any staining with polymorphonuclear neutrophils and erythrocytes.
Supplier:
Diagnostic Biosystems
Description:
The clone F7.2.38 is specific for the non-glycosylated epsilon chain of the human CD3 molecule. Clone F7.2.38 recognizes T cells in the thymus, bone marrow, peripheral lymphoid tissue and blood and is a pan T cell marker. The CD3 molecule consists of five different polypeptide chains with molecular weights ranging from 16 to 28 kDa. The CD3 antigen is first detected in early thymocytes, and its appearance probably represents one of the earliest signs of commitment to the T cell lineage.
Supplier:
Diagnostic Biosystems
Description:
Monoclonal anti-smooth muscle myosin reacts with myosin heavy chain polypeptides of 200 and 204 kDa. It does not react with skeletal, cardiac, or non-muscle myosin. In immunohistochemistry it stains vascular and visceral smooth muscle cells and cells that have smooth muscle-like characteristics.
Supplier:
Diagnostic Biosystems
Description:
This antibody recognizes a protein of 38kDa, identified as synaptophysin. It labels normal neuroendocrine cells of human adrenal medulla, carotid body, skin, pituitary gland, thyroid, lung, pancreas, gastrointestinal mucosa, Paneth’s cells in the gastrointestinal tract and gastric parietal cells. Neurons in the brain, spinal cord, and retina are also labeled. In combination with anti-chromogranin A and anti-NSE, anti-synaptophysin is very useful in the identification of normal neuroendocrine cells and neuroendocrine neoplasms.
Catalog Number:
(76634-904)
Supplier:
Diagnostic Biosystems
Description:
This antibody recognizes a c-erbB-2 protein, which is a receptor tyrosine kinase of the c-erbB family. It is closely related in structure to the epidermal growth factor receptor. c-erbB-2 oncoprotein is detectable in a subset of breast and other adenocarcinomas, as well as transitional cell carcinomas. In the case of breast cancer, expression determined by immunohistochemistry has been shown to be associated with poor prognosis.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with a 180 kDa protein, known as Flt-1 or vascular endothelial growth factor receptor 1 (VEGFR1). Flt-1 is a cell membrane receptor kinase. Flk-1 has a high affinity receptor for vascular endothelial growth factor and is putatively involved in the growth of endothelial cells and angiogenesis.
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to α-smooth muscle isoform of actin. It reacts with smooth muscle cells of vessels and different parenchymes.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with a 32 kDa protein. Granzymes are neutral serine proteases, which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTL) and in natural killer (NK) cells. A number of granzymes (A to G) have been isolated and cloned. Human granzyme B is involved in target cell apoptosis during lymphocyte-mediated cytotoxicity. This antibody is useful in the localization of granzyme B containing lytic granules and for the characterization of activated CTL or NK cells.
Catalog Number:
(10065-080)
Supplier:
Diagnostic Biosystems
Description:
Monoclonal mouse Antibody-Human Mast Cell Chymase, Clone CC1, Isotype IgG1, Immunogen: BALB/C mice were injected with a purified human skin chymase. Prediluted 6 ml.
Catalog Number:
(99990-090)
Supplier:
Diagnostic Biosystems
Description:
Proteinase K is specifically formulated to achieve proteolytic digestion of formalin fixed, paraffin embedded tissue sections prior to performing <i>in situ</i> hybridization procedures.
Catalog Number:
(76634-424)
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with mast cells distributed in skin, synovium, lung, and heart. This antibody does not bind with any other cell type. Mast cells contain a number of preformed chemicals mediators such as histamine, chymase, carboxypeptidase, and proteolytic tryptase. Human mast cell tryptase is considered to be an important marker of mast cell activation and is an important mediator of inflammation.
Catalog Number:
(76634-290)
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with the 57 kDa intermediate filament protein present in the cells of mesenchymal origin. The antibody does not show any cross-reactivity with other intermediate filament proteins. However, it shows a broad interspecies cross-reactivity.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with a 70 kDa protein. COX-2 (Cyclooxygenase-2) is an inducible enzyme. It is involved in the response of cells to growth factors, tumor promoters and cytokines that induce its expression. COX-2 expression markedly increased in 85-90% of human colorectal adenocarcinoma whereas COX-1 levels remained unchanged.
Catalog Number:
(76634-536)
Supplier:
Diagnostic Biosystems
Description:
Glypican-3 (GPC3) is a glycosylphospatidyl inositol-anchored membrane protein, which may also be found in a secreted form. Anti-GPC3 has been identified as a useful tumor marker for the diagnosis of hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and Wilms' tumor. In patients with HCC, GPC3 is overexpressed in neoplastic liver tissue and elevated in serum, but is undetectable in normal liver, benign liver, and the serum of healthy donors. GPC3 expression is also found to be higher in HCC liver tissue than in cirrhotic liver or liver with focal lesions such as dysplastic nodules and areas of hepatic adenoma (HA) with malignant transformation. In the context of testicular germ cell tumors, GPC3 expression is up regulated in certain histologic subtypes, specifically yolk sac tumors and choriocarcinoma. A high level of GPC3 expression is also found in some types of embryonal tumors, such as Wilms' tumor and hepatoblastoma, with a low or undetectable expression in normal adjacent tissue. In patients with thyroid cancer, expression of GPC3 is dramatically enhanced in certain types of cancers: 100% in follicular carcinoma and 70% in papillary carcinoma. Expression of GPC3 in follicular carcinoma is significantly higher than that offollicular adenoma.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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