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DIAGNOSTIC BIOSYSTEMS INC
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DIAGNOSTIC BIOSYSTEMS INC
Catalog Number:
(76634-084)
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to a 70 kDa protein, which is a potent cytolytic pore-forming protein. Perforin is a specific marker of functionally active cytotoxic T-lymphocytes and natural killer cells. Perforin mediates cytolysis of target cells by membrane damage and apoptosis.
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to a protein of 28 kDa. Calbindin-D-28K is also known as vitamin D-dependent calcium-binding protein or cholecalcin. Calbindin D-28K has a broad tissue distribution; however, it exhibits a cell type-specific expression pattern. This antibody reacts specifically with calbindin-D-28K in brain and kidney tissues.
Catalog Number:
(76634-450)
Supplier:
Diagnostic Biosystems
Description:
Monoclonal anti-smooth muscle myosin reacts with myosin heavy chain polypeptides of 200 and 204 kDa. It does not react with skeletal, cardiac, or non-muscle myosin. In immunohistochemistry it stains vascular and visceral smooth muscle cells and cells that have smooth muscle-like characteristics.
Supplier:
Diagnostic Biosystems
Description:
PRAME (Preferentially expressed Antigen in Melanoma) is a tumorassociated antigen and is a member of the family of cancer testis antigens (CTA). PRAME is expressed in malignant cells, including leukaemias, Hodgkin's lymphoma, breast cancer, and primary and metastatic melanomas. PRAME has low or no expression in normal tissues except for in testis, ovary, placenta, adrenals and endometrium.
Catalog Number:
(76634-880)
Supplier:
Diagnostic Biosystems
Description:
p63 is a homolog of the tumor suppressor p53, it is identified in basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium, breast and prostate. p63, vital for the development of the prostate and selectively expressed by normal prostate basal cells, has been shown to be a promising complementary basal cell specific marker to High Molecular Weight-Cytokeratin (HMW-CK), for the differential diagnosis of benign prostatic lesions and prostatic carcinoma. p63 has also been shown to be a sensitive marker for lung squamous cell carcinomas (SqCC), with a sensitivity of ~90% . Specificity for lung SqCC, vs. lung adenocarcinoma (LADC), is approximately 80. In breast tissue, p63 has been identified in myoepithelial cells of normal ducts.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with the zymogen as well as the activated form of cathepsin D. It stains fibroblasts and macrophages strongly but stains weakly with the myoepithelial cells of breast. It stains the sweat ducts and glands in the skin, islets cells and granules of pancreatic acini.
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to a 38 kDa protein. Synaptophysin is an glycoprotein occurring in presynaptic vesicles of neurons in the brain, spinal cord, retina, vesicles of adrenal medulla and in neuromuscular junctions. This antibody reacts with neuroendocrine neoplasms of neural as well as epithelial types.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with a 33-36 kDa protein known as ERCC1 (excision repair cross complementing) polypeptide. ERCC1 is required for nucleotide excision repair of damaged DNA and is homologous to RAD10. In mammalian cells, XPG cleaves 3’ of the DNA lesion while ERCC1-XPF complex makes the 5’ incision.
Supplier:
Diagnostic Biosystems
Description:
Cytokeratin 20 is less acidic than the other type I cytokeratins and is of particular interest because of its restricted range of expression. This antibody reacts with cytokeratin polypeptide of 46 kDa in immunoblot analyses. Studies have shown that a marked difference exists in the expression of Cytokeratin 20 among various carcinomas.
Catalog Number:
(76634-886)
Supplier:
Diagnostic Biosystems
Description:
ROS1 rearrangements occur infrequently in lung ACA, however given the frequency of lung cancer in the population, ROS1-rearranged tumors represent a significant number of cancer patients. ROS1 gene rearrangements are reported in 1 to 2% of lung adenocarcinomas (ACA) and are associated with response to the multitargeted tyrosine kinase inhibitor, crizotinib. ROS IHC can be readily incorporated into the diagnostic surgical pathology workup of lung adenocarcinoma, with results confirmed by FISH as needed.
Catalog Number:
(76634-390)
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with cytokeratin 5 intermediate filament protein. Basal cells of human epidermis express acidic cytokeratin 14 and basic cytokeratin 5. Cytokeratin 5 is a 58 kDa protein, which is closely related to cytokeratin 6. Cytokeratin 5 and 6 are expressed in basal cell epithelioma, basal cells of prostate, urothelium, vagina, squamous cell carcinomas of skin, tongue, epiglottis and rectal-anal region. Cytokeratin 5 can be useful in the distinction of mesotheliomas from most adenocarcinomas.
Catalog Number:
(76634-388)
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to 50 kDa cytokeratin protein designated cytokeratin 14. Cytokeratin 14 belongs to the type A (acidic) subfamily of low molecular weight cytokeratins and exists in combination with cytokeratin 15. This antibody can be used to distinguish stratified epithelial cells from simple epithelial cells.
Supplier:
Diagnostic Biosystems
Description:
The bcl-2 product is considered to act as an inhibitor of apoptosis. Bcl-2 expression is inhibited in germinal centers where apoptosis forms part of the B cell production pathway. Reactive follicles show no staining for bcl-2, whereas the cells in neoplastic follicles exhibit membrane staining. Bcl-2 α oncoprotein has been shown to inhibit apoptosis.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with human albumin. This antibody is essentially free of other rabbit serum proteins. Specificity is determined by Ouchterlony double diffusion (ODD) and immunoelectrophoresis (IEP) versus human serum and human albumin.
Catalog Number:
(95027-180)
Supplier:
Diagnostic Biosystems
Description:
This kit stains amyloid deposits in paraffin tissue sections
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to human CD10 antigen of 100 kDa, also known as common acute lymphocytic leukemia antigen (CALLA). CD10 antigen has been identified on the surface of early lymphoid progenitor cells, immature B cells within adult bone marrow and germinal center B cells within lymphoid tissue.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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